Impact of Demographics and Clinical Features on Initial Treatment Pathway for Vestibular Schwannoma. Otol Neurotol 2022 Oct 01;43(9):1078-1084
Date
08/13/2022Pubmed ID
35960883Pubmed Central ID
PMC9878333DOI
10.1097/MAO.0000000000003652Scopus ID
2-s2.0-85138449091 (requires institutional sign-in at Scopus site) 1 CitationAbstract
OBJECTIVE: To identify demographic and clinical features impacting initial treatment pathway for vestibular schwannoma.
STUDY DESIGN: Retrospective chart review.
SETTING: Tertiary care academic medical center.
PATIENTS: Patients diagnosed with vestibular schwannoma between 2009 and 2019.
INTERVENTIONS: Observation, stereotactic radiosurgery, or microsurgical resection.
MAIN OUTCOME MEASURES: χ 2 Test, one-way analysis of variance, and multivariate logistic regression were used to correlate demographic and clinical factors with initial treatment pathway for 197 newly diagnosed vestibular schwannoma patients.
RESULTS: Among 197 patients, 93 (47%) were initially treated with observation, 60 (30%) with stereotactic radiation (Gamma Knife) and 44 (22%) with surgical resection. Age univariately had no statistically significant impact on initial pathway, but those undergoing surgery trended toward a younger demographic (49.1 yr [surgery] versus 57.2 yr [observation] versus 59.0 yr [Gamma Knife]). Men were more likely to be initially observed than women ( p = 0.04). Patients initially observed were more likely to have a lower Koos classification ( p < 0.001) and have better tumor-ear hearing ( p = 0.03). Only 34.4% of patients living outside the local geographic region were initially observed compared with 53.0% living locally ( p = 0.055). Surgeon correlated with initial treatment ( p = 0.04) but did not maintain significance when adjusting for hearing level or tumor size. A multiple linear regression model found age, maximum tumor diameter, and Koos class to correlate with initial treatment pathway ( p < 0.0001, r2 = 0.42).
CONCLUSION: Initial treatment pathway for newly diagnosed vestibular schwannoma is impacted by demographic factors such as age, sex, and geographic proximity to the medical center. Clinical features including hearing level and tumor size also correlated with initial treatment modality.
Author List
Harvey E, Stark K, Friedland DR, Adams JA, Harris MS, Tong L, Osinksi K, Luo JAuthors
David R. Friedland MD Associate Director, Director, Chief, Professor in the Otolaryngology department at Medical College of WisconsinMichael S. Harris MD Associate Professor in the Otolaryngology department at Medical College of Wisconsin
Jake Luo Ph.D. Associate Professor; Director, Center for Biomedical Data and Language Processing (BioDLP) in the Health Informatics & Administration department at University of Wisconsin - Milwaukee
MESH terms used to index this publication - Major topics in bold
DemographyFemale
Humans
Male
Neuroma, Acoustic
Radiosurgery
Retrospective Studies
Treatment Outcome
