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Sensitivity enhancement in static solid-state NMR experiments via single- and multiple-quantum dipolar coherences. J Am Chem Soc 2009 Apr 29;131(16):5754-6

Date

04/09/2009

Pubmed ID

19351170

Pubmed Central ID

PMC3481552

DOI

10.1021/ja900096d

Scopus ID

2-s2.0-70149102210 (requires institutional sign-in at Scopus site)   49 Citations

Abstract

We present a new method for enhancing the sensitivity in static solid-state NMR experiments for a gain in signal-to-noise ratio of up to 40%. This sensitivity enhancement is different from the corresponding solution NMR sensitivity enhancement schemes and is achieved by combining single- and multiple-quantum dipolar coherences. While this new approach is demonstrated for the polarization inversion spin exchange at magic angle (PISEMA) experiment, it can be generalized to the other separated local field experiments for solid-state NMR spectroscopy. This method will have a direct impact on solid-state NMR spectroscopy of liquid crystals as well as of membrane proteins aligned in lipid membranes.

Author List

Gopinath T, Veglia G

Author

Gopinath Tata PhD Assistant Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Crystallization
Leucine
Nuclear Magnetic Resonance, Biomolecular
Sensitivity and Specificity