Sucrose Nonfermenting-Related Kinase Expression Is Related to a Metabolic Switch in Ovarian Cancer Cells That Results in Increased Fatty Acid Oxidation. Cancer Invest 2023 Apr;41(4):330-344
Date
10/14/2022Pubmed ID
36227231DOI
10.1080/07357907.2022.2136376Scopus ID
2-s2.0-85145817960 (requires institutional sign-in at Scopus site)Abstract
Ovarian cancer frequently metastasizes to the omentum, which is primarily comprised of adipocytes. Our previous study found that sucrose nonfermenting-related kinase (SNRK) expression is lower in advanced-stage compared with early-stage ovarian cancer tissue. In this study, SNRK knockdown was performed in ovarian cancer cell lines using lentiviral transduction and resulted in decreased cell proliferation, increased invasion, and a switch in metabolism to increased fatty acid oxidation (FAO). Our data suggest that SNRK works as a metabolic checkpoint that allows for oxidative phosphorylation and prevents FAO during a time of rapid tumor growth.
Author List
Chowdhury S, Ramchandran R, Palecek SP, Acevedo-Acevedo S, Bishop EAuthors
Erin Bishop MD Associate Professor in the Obstetrics and Gynecology department at Medical College of WisconsinRamani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Cell LineFatty Acids
Female
Humans
Ovarian Neoplasms
