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Ramani Ramchandran PhD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Neonatology

Member of the Cancer Center
Member of the Cardiovascular Center

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Publications (107)

Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations. (Wan T, Rousseau H, Mattern C, Tabor M, Hodges MR, Ramchandran R, Spearman AD) bioRxiv 2024 Apr 05 PMID: 38617317 PMCID: PMC11014550 04/15/2024

Brain microvascular endothelial cells possess a second cilium that arises from the daughter centriole. (Thirugnanam K, Gupta A, Nunez F, Prabhudesai S, Pan AY, Nauli SM, Ramchandran R) Front Mol Biosci 2023;10:1250016 PMID: 38028541 PMCID: PMC10657992 SCOPUS ID: 2-s2.0-85177189351 11/29/2023

Editorial: Editors' showcase-insights into molecular and cellular pathology. (Ramchandran R, Del Fattore A, Wingert RA) Front Cell Dev Biol 2023;11:1235103 PMID: 37389356 PMCID: PMC10303773 SCOPUS ID: 2-s2.0-85163782244 06/30/2023

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2023 Mar 28;42(3):112228 PMID: 36884347 PMCID: PMC10233815 SCOPUS ID: 2-s2.0-85149682952 03/09/2023

Brain microvascular endothelial cells possess a second cilium that arises from the daughter centriole (Thirugnanam K, Gupta A, Nunez F, Prabhudesai S, Pan AY, Nauli SM, Ramchandran R) Frontiers in Molecular Biosciences 2023;10 SCOPUS ID: 2-s2.0-85177189351 01/01/2023

Sucrose Nonfermenting-Related Kinase Expression Is Related to a Metabolic Switch in Ovarian Cancer Cells That Results in Increased Fatty Acid Oxidation. (Chowdhury S, Ramchandran R, Palecek SP, Acevedo-Acevedo S, Bishop E) Cancer Invest 2023 Apr;41(4):330-344 PMID: 36227231 SCOPUS ID: 2-s2.0-85145817960 10/14/2022

Endothelial cells and their role in the vasculature: Past, present and future. (Ramchandran R) Front Cell Dev Biol 2022;10:994133 PMID: 36187473 PMCID: PMC9520988 SCOPUS ID: 2-s2.0-85139184351 10/04/2022 1 Citation

Hepatic factor may not originate from hepatocytes. (Merbach M, Ramchandran R, Spearman AD) Front Cardiovasc Med 2022;9:999315 PMID: 36148055 PMCID: PMC9486074 SCOPUS ID: 2-s2.0-85138339927 09/24/2022

Endothelial cells and their role in the vasculature: Past, present and future (Ramchandran R) Frontiers in Cell and Developmental Biology 15 September 2022;10 SCOPUS ID: 2-s2.0-85139184351 09/15/2022 1 Citation

Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development. (Zakaria ZZ, Eisa-Beygi S, Benslimane FM, Ramchandran R, Yalcin HC) J Vis Exp 2022 Aug 09(186) PMID: 36036621 PMCID: PMC10388372 SCOPUS ID: 2-s2.0-85136787659 08/30/2022 1 Citation

Integrated Excitatory/Inhibitory Imbalance and Transcriptomic Analysis Reveals the Association between Dysregulated Synaptic Genes and Anesthetic-Induced Cognitive Dysfunction. (Yan Y, Logan S, Liu X, Chen B, Jiang C, Arzua T, Ramchandran R, Liu QS, Bai X) Cells 2022 Aug 11;11(16) PMID: 36010580 PMCID: PMC9406780 SCOPUS ID: 2-s2.0-85136592621 08/27/2022 4 Citations

Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. (Thirugnanam K, Prabhudesai S, Van Why E, Pan A, Gupta A, Foreman K, Zennadi R, Rarick KR, Nauli SM, Palecek SP, Ramchandran R) Biochem Pharmacol 2022 Aug;202:115143 PMID: 35700757 SCOPUS ID: 2-s2.0-85132215893 06/15/2022 4 Citations

Coagulation Factor IIIa (f3a) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype. (Subramaniam S, Liu J, Fletcher C, Ramchandran R, Weiler H) Front Cell Dev Biol 2022;10:852989 PMID: 35386206 PMCID: PMC8978257 SCOPUS ID: 2-s2.0-85128081688 04/08/2022 1 Citation

Cilia proteins are biomarkers of altered flow in the vasculature. (Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R) JCI Insight 2022 Mar 22;7(6) PMID: 35143420 PMCID: PMC8986075 SCOPUS ID: 2-s2.0-85127051401 02/11/2022 3 Citations

Editorial: Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity. (Ren B, Ramchandran R, Yang X) Front Cell Dev Biol 2021;9:821100 PMID: 34977049 PMCID: PMC8718799 SCOPUS ID: 2-s2.0-85122085213 01/04/2022 1 Citation

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2021 Nov 02;37(5):109934 PMID: 34731628 PMCID: PMC8675433 SCOPUS ID: 2-s2.0-85118477211 11/04/2021 31 Citations

The Yin and the Yang of Transformative Research During the COVID-19 Pandemic-A Perspective. (Sampath V, Ramchandran R) Front Pediatr 2021;9:650302 PMID: 34249804 PMCID: PMC8264183 SCOPUS ID: 2-s2.0-85109960600 07/13/2021

sVEGFR1 Is Enriched in Hepatic Vein Blood-Evidence for a Provisional Hepatic Factor Candidate? (Spearman AD, Gupta A, Pan AY, Gudausky TM, Foerster SR, Konduri GG, Ramchandran R) Front Pediatr 2021;9:679572 PMID: 34195162 PMCID: PMC8236596 SCOPUS ID: 2-s2.0-85115450112 07/02/2021 3 Citations

Established, New and Emerging Concepts in Brain Vascular Development. (Gupta A, Rarick KR, Ramchandran R) Front Physiol 2021;12:636736 PMID: 33643074 PMCID: PMC7907611 SCOPUS ID: 2-s2.0-85101814691 03/02/2021 14 Citations

DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling. (Bogush N, Tan L, Naib H, Faizullabhoy E, Calvert JW, Iismaa SE, Gupta A, Ramchandran R, Martin DIK, Graham RM, Husain A, Naqvi N) Sci Rep 2020 Dec 14;10(1):21918 PMID: 33318551 PMCID: PMC7736286 SCOPUS ID: 2-s2.0-85098475715 12/16/2020 13 Citations

Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling. (Parashar D, Nair B, Geethadevi A, George J, Nair A, Tsaih SW, Kadamberi IP, Gopinadhan Nair GK, Lu Y, Ramchandran R, Uyar DS, Rader JS, Ram PT, Mills GB, Pradeep S, Chaluvally-Raghavan P) Cancer Res 2020 Dec 15;80(24):5554-5568 PMID: 33087324 PMCID: PMC7744365 SCOPUS ID: 2-s2.0-85100331032 10/23/2020 25 Citations

SNRK: a metabolic regulator with multifaceted role in development and disease. (Thirugnanam K, Ramchandran R) Vessel Plus 2020;4 PMID: 32968716 PMCID: PMC7508454 09/25/2020

Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2. (Dey A, Prabhudesai S, Zhang Y, Rao G, Thirugnanam K, Hossen MN, Dwivedi SKD, Ramchandran R, Mukherjee P, Bhattacharya R) Sci Adv 2020 Jul;6(27) PMID: 32937467 PMCID: PMC7458453 SCOPUS ID: 2-s2.0-85088472971 09/17/2020 25 Citations

Astrocytes influence medulloblastoma phenotypes and CD133 surface expression. (Gronseth E, Gupta A, Koceja C, Kumar S, Kutty RG, Rarick K, Wang L, Ramchandran R) PLoS One 2020;15(7):e0235852 PMID: 32628717 PMCID: PMC7337293 SCOPUS ID: 2-s2.0-85087672966 07/07/2020 12 Citations

Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells. (Jamal MH, Nunes ACF, Vaziri ND, Ramchandran R, Bacallao RL, Nauli AM, Nauli SM) Biochem Pharmacol 2020 Aug;178:114056 PMID: 32470549 PMCID: PMC7899243 SCOPUS ID: 2-s2.0-85085767157 05/30/2020 10 Citations

Hepatic Vein Blood Increases Lung Microvascular Angiogenesis and Endothelial Cell Survival-Toward an Understanding of Univentricular Circulation. (Spearman AD, Gupta A, Pan AY, Gronseth EI, Thirugnanam K, Gudausky TM, Foerster SR, Ramchandran R) Semin Thorac Cardiovasc Surg 2020 Winter;32(4):980-987 PMID: 32387780 PMCID: PMC7647938 SCOPUS ID: 2-s2.0-85086171858 05/11/2020 7 Citations

ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis. (Chen C, Gupta P, Parashar D, Nair GG, George J, Geethadevi A, Wang W, Tsaih SW, Bradley W, Ramchandran R, Rader JS, Chaluvally-Raghavan P, Pradeep S) Oncogene 2020 Apr;39(14):2921-2933 PMID: 32029900 PMCID: PMC7346970 SCOPUS ID: 2-s2.0-85079196544 02/08/2020 27 Citations

SNRK: A metabolic regulator with multifaceted role in development and disease (Thirugnanam K, Ramchandran R) Vessel Plus 2020;4 SCOPUS ID: 2-s2.0-85118921209 01/01/2020 4 Citations

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. (Parashar D, Geethadevi A, Aure MR, Mishra J, George J, Chen C, Mishra MK, Tahiri A, Zhao W, Nair B, Lu Y, Mangala LS, Rodriguez-Aguayo C, Lopez-Berestein G, Camara AKS, Liang M, Rader JS, Ramchandran R, You M, Sood AK, Kristensen VN, Mills GB, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2019 Dec 24;29(13):4389-4406.e10 PMID: 31875548 PMCID: PMC7380555 SCOPUS ID: 2-s2.0-85076674271 12/26/2019 54 Citations

Discovery and Characterization of Halogenated Xanthene Inhibitors of DUSP5 as Potential Photodynamic Therapeutics. (Bongard RD, Lepley M, Gastonguay A, Syrlybaeva RR, Talipov MR, Lipinsky RAJ, Leigh NR, Brahmbhatt J, Kutty R, Rathore R, Ramchandran R, Sem DS) J Photochem Photobiol A Chem 2019 Apr 15;375:114-131 PMID: 31839699 PMCID: PMC6910256 SCOPUS ID: 2-s2.0-85061777995 12/17/2019 6 Citations

Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. (Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, Spearman AD, Sonin DL, Bordas M, Kumar SN, Pan AY, Simpson PM, Strande JL, Bishop E, Zou MH, Ramchandran R) J Am Heart Assoc 2019 Nov 19;8(22):e012792 PMID: 31718444 PMCID: PMC6915262 SCOPUS ID: 2-s2.0-85075040816 11/14/2019 9 Citations

Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes. (Gong X, Hou Z, Endsley MP, Gronseth EI, Rarick KR, Jorns JM, Yang Q, Du Z, Yan K, Bordas ML, Gershan J, Deepak P, Geethadevi A, Chaluvally-Raghavan P, Fan Y, Harder DR, Ramchandran R, Wang L) NPJ Precis Oncol 2019;3:24 PMID: 31602400 PMCID: PMC6776663 SCOPUS ID: 2-s2.0-85079332436 10/12/2019 52 Citations

Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1. (Chowdhury TA, Li K, Ramchandran R) Vascul Pharmacol 2019 Mar;114:103-109 PMID: 30910126 PMCID: PMC6436643 SCOPUS ID: 2-s2.0-85048843519 03/27/2019 3 Citations

Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5. (Gupta A, Brahmbhatt J, Syrlybaeva R, Bodnar C, Bodnar N, Bongard R, Pokkuluri PR, Sem DS, Ramchandran R, Rathore R, Talipov MR) J Chem Inf Model 2019 Apr 22;59(4):1563-1574 PMID: 30835471 SCOPUS ID: 2-s2.0-85064712113 03/06/2019 1 Citation

Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio). (Eisa-Beygi S, Benslimane FM, El-Rass S, Prabhudesai S, Abdelrasoul MKA, Simpson PM, Yalcin HC, Burrows PE, Ramchandran R) Arterioscler Thromb Vasc Biol 2018 Dec;38(12):2806-2818 PMID: 30571172 PMCID: PMC6309420 SCOPUS ID: 2-s2.0-85058925854 12/21/2018 38 Citations

Corrigendum: Cystathionine β-Synthase Is Necessary for Axis Development in vivo. (Prabhudesai S, Koceja C, Dey A, Eisa-Beygi S, Leigh NR, Bhattacharya R, Mukherjee P, Ramchandran R) Front Cell Dev Biol 2018;6:121 PMID: 30310813 PMCID: PMC6171515 SCOPUS ID: 2-s2.0-85054272337 10/13/2018 8 Citations

Correction to "Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs". (Talipov MR, Nayak J, Lepley M, Bongard RD, Sem DS, Ramchandran R, Rathore R) Biochemistry 2018 Jul 03;57(26):3987 PMID: 29897735 SCOPUS ID: 2-s2.0-85049525960 06/14/2018

Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly. (Chowdhury TA, Koceja C, Eisa-Beygi S, Kleinstiver BP, Kumar SN, Lin CW, Li K, Prabhudesai S, Joung JK, Ramchandran R) Arterioscler Thromb Vasc Biol 2018 Jul;38(7):1562-1575 PMID: 29724820 PMCID: PMC6023729 SCOPUS ID: 2-s2.0-85054442764 05/05/2018 18 Citations

Correction: RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells (doi:10.1242/jcs.167601). (Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D) J Cell Sci 2018 Mar 16;131(6) PMID: 29549170 PMCID: PMC6295134 SCOPUS ID: 2-s2.0-85045917783 03/20/2018 2 Citations

Cystathionine β-Synthase Is Necessary for Axis Development in Vivo. (Prabhudesai S, Koceja C, Dey A, Eisa-Beygi S, Leigh NR, Bhattacharya R, Mukherjee P, Ramchandran R) Front Cell Dev Biol 2018;6:14 PMID: 29503817 PMCID: PMC5820354 SCOPUS ID: 2-s2.0-85042077038 03/06/2018 7 Citations

SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo. (Lu Q, Xie Z, Yan C, Ding Y, Ma Z, Wu S, Qiu Y, Cossette SM, Bordas M, Ramchandran R, Zou MH) Arterioscler Thromb Vasc Biol 2018 Feb;38(2):373-385 PMID: 29242271 PMCID: PMC5785416 SCOPUS ID: 2-s2.0-85048412101 12/16/2017 28 Citations

Dual Specificity Phosphatase 5-Substrate Interaction: A Mechanistic Perspective. (Kutty RG, Talipov MR, Bongard RD, Lipinski RAJ, Sweeney NL, Sem DS, Rathore R, Ramchandran R) Compr Physiol 2017 Sep 12;7(4):1449-1461 PMID: 28915331 SCOPUS ID: 2-s2.0-85045328175 09/16/2017 16 Citations

Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features. (Hopp EE, Cossette SM, Kumar SN, Eastwood D, Ramchandran R, Bishop E) Cancer Invest 2017 Aug 09;35(7):456-462 PMID: 28722495 PMCID: PMC6167932 SCOPUS ID: 2-s2.0-85025168444 07/20/2017 4 Citations

miRNA-Mediated RNA Activation in Mammalian Cells. (Ramchandran R, Chaluvally-Raghavan P) Adv Exp Med Biol 2017;983:81-89 PMID: 28639193 SCOPUS ID: 2-s2.0-85021314316 06/24/2017 41 Citations

Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor. (Bongard RD, Lepley M, Thakur K, Talipov MR, Nayak J, Lipinski RAJ, Bohl C, Sweeney N, Ramchandran R, Rathore R, Sem DS) BMC Biochem 2017 May 31;18(1):10 PMID: 28569147 PMCID: PMC5452347 SCOPUS ID: 2-s2.0-85019734713 06/02/2017 7 Citations

Dual Specificity Phosphatase 5 Is Essential for T Cell Survival. (Kutty RG, Xin G, Schauder DM, Cossette SM, Bordas M, Cui W, Ramchandran R) PLoS One 2016;11(12):e0167246 PMID: 27936095 PMCID: PMC5147890 SCOPUS ID: 2-s2.0-85006064690 12/10/2016 15 Citations

Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function. (Cossette SM, Bhute VJ, Bao X, Harmann LM, Horswill MA, Sinha I, Gastonguay A, Pooya S, Bordas M, Kumar SN, Mirza SP, Palecek SP, Strande JL, Ramchandran R) Circ Cardiovasc Genet 2016 Dec;9(6):474-486 PMID: 27780848 PMCID: PMC5177517 SCOPUS ID: 2-s2.0-85007206187 10/27/2016 13 Citations

Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs. (Talipov MR, Nayak J, Lepley M, Bongard RD, Sem DS, Ramchandran R, Rathore R) Biochemistry 2016 Nov 08;55(44):6187-6195 PMID: 27739308 SCOPUS ID: 2-s2.0-84994689545 10/16/2016 5 Citations

E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells. (Palen K, Weber J, Dwinell MB, Johnson BD, Ramchandran R, Gershan JA) Oncotarget 2016 Jul 12;7(28):43363-43375 PMID: 27270319 PMCID: PMC5190029 SCOPUS ID: 2-s2.0-84978710944 06/09/2016 19 Citations

The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis. (Iden M, Fye S, Li K, Chowdhury T, Ramchandran R, Rader JS) PLoS One 2016;11(5):e0156274 PMID: 27232880 PMCID: PMC4883781 SCOPUS ID: 2-s2.0-84971607454 05/28/2016 137 Citations

Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. (Rana U, Liu Z, Kumar SN, Zhao B, Hu W, Bordas M, Cossette S, Szabo S, Foeckler J, Weiler H, Chrzanowska-Wodnicka M, Holtz ML, Misra RP, Salato V, North PE, Ramchandran R, Miao QR) Dev Biol 2016 Feb 15;410(2):190-201 PMID: 26746789 PMCID: PMC4767500 SCOPUS ID: 2-s2.0-84957847497 01/10/2016 19 Citations

Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway. (Kilari S, Cossette S, Pooya S, Bordas M, Huang YW, Ramchandran R, Wilkinson GA) PLoS One 2015;10(12):e0144185 PMID: 26692198 PMCID: PMC4686900 SCOPUS ID: 2-s2.0-84956927768 12/23/2015 8 Citations

Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration. (Saha S, Chakraborty PK, Xiong X, Dwivedi SK, Mustafi SB, Leigh NR, Ramchandran R, Mukherjee P, Bhattacharya R) FASEB J 2016 Jan;30(1):441-56 PMID: 26405298 PMCID: PMC4684530 SCOPUS ID: 2-s2.0-84974855984 09/26/2015 104 Citations

Correction: Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2015;10(8):e0137369 PMID: 26322640 PMCID: PMC4554722 SCOPUS ID: 2-s2.0-84943279669 09/01/2015 2 Citations

Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets. (Neumann TS, Span EA, Kalous KS, Bongard R, Gastonguay A, Lepley MA, Kutty RG, Nayak J, Bohl C, Lange RG, Sarker MI, Talipov MR, Rathore R, Ramchandran R, Sem DS) BMC Biochem 2015 Aug 19;16:19 PMID: 26286528 PMCID: PMC4545774 SCOPUS ID: 2-s2.0-84939424042 08/20/2015 8 Citations

Gene Expression in Experimental Aortic Coarctation and Repair: Candidate Genes for Therapeutic Intervention? (LaDisa JF Jr, Bozdag S, Olson J, Ramchandran R, Kersten JR, Eddinger TJ) PLoS One 2015;10(7):e0133356 PMID: 26207811 PMCID: PMC4514739 SCOPUS ID: 2-s2.0-84941695738 07/25/2015 6 Citations

RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. (Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun C, Ramchandran R, Ekker SC, Mukhopadhyay D) J Cell Sci 2015 Oct 01;128(19):3556-68 PMID: 26136364 PMCID: PMC4647168 SCOPUS ID: 2-s2.0-84946082846 07/03/2015 36 Citations

SIGIRR genetic variants in premature infants with necrotizing enterocolitis. (Sampath V, Menden H, Helbling D, Li K, Gastonguay A, Ramchandran R, Dimmock DP) Pediatrics 2015 Jun;135(6):e1530-4 PMID: 25963006 PMCID: PMC4444800 SCOPUS ID: 2-s2.0-84930607947 05/13/2015 69 Citations

Delta-like 4 mRNA is regulated by adjacent natural antisense transcripts. (Li K, Chowdhury T, Vakeel P, Koceja C, Sampath V, Ramchandran R) Vasc Cell 2015;7:3 PMID: 25914805 PMCID: PMC4409748 SCOPUS ID: 2-s2.0-84928338548 04/29/2015 15 Citations

Organization for rare diseases India (ORDI) - addressing the challenges and opportunities for the Indian rare diseases' community. (Rajasimha HK, Shirol PB, Ramamoorthy P, Hegde M, Barde S, Chandru V, Ravinandan ME, Ramchandran R, Haldar K, Lin JC, Babar IA, Girisha KM, Srinivasan S, Navaneetham D, Battu R, Devarakonda R, Kini U, Vijayachandra K, Verma IC) Genet Res (Camb) 2014 Aug 13;96:e009 PMID: 25579084 PMCID: PMC7044965 SCOPUS ID: 2-s2.0-84940995950 01/13/2015 24 Citations

Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells. (Menden H, Welak S, Cossette S, Ramchandran R, Sampath V) J Biol Chem 2015 Feb 27;290(9):5449-61 PMID: 25568324 PMCID: PMC4342461 SCOPUS ID: 2-s2.0-84923766524 01/09/2015 63 Citations

Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins. (Nayak J, Gastonguay AJ, Talipov MR, Vakeel P, Span EA, Kalous KS, Kutty RG, Jensen DR, Pokkuluri PR, Sem DS, Rathore R, Ramchandran R) BMC Biochem 2014 Dec 18;15:27 PMID: 25519881 PMCID: PMC4299175 SCOPUS ID: 2-s2.0-84924158080 12/19/2014 10 Citations

Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. (Cossette SM, Gastonguay AJ, Bao X, Lerch-Gaggl A, Zhong L, Harmann LM, Koceja C, Miao RQ, Vakeel P, Chun C, Li K, Foeckler J, Bordas M, Weiler H, Strande J, Palecek SP, Ramchandran R) Biol Open 2014 Dec 12;4(1):48-61 PMID: 25505152 PMCID: PMC4295165 SCOPUS ID: 2-s2.0-84979987693 12/17/2014 19 Citations

Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. (Schupp MO, Waas M, Chun CZ, Ramchandran R) Dev Biol 2014 Sep 01;393(1):71-83 PMID: 24984259 PMCID: PMC4137469 SCOPUS ID: 2-s2.0-84905732091 07/02/2014 15 Citations

Astrocytes directly influence tumor cell invasion and metastasis in vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2013;8(12):e80933 PMID: 24324647 PMCID: PMC3851470 SCOPUS ID: 2-s2.0-84891893696 12/11/2013 76 Citations

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. (Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X) Hum Mol Genet 2014 Mar 15;23(6):1644-55 PMID: 24203696 PMCID: PMC3929098 SCOPUS ID: 2-s2.0-84894366738 11/10/2013 39 Citations

Mmp17b is essential for proper neural crest cell migration in vivo. (Leigh NR, Schupp MO, Li K, Padmanabhan V, Gastonguay A, Wang L, Chun CZ, Wilkinson GA, Ramchandran R) PLoS One 2013;8(10):e76484 PMID: 24098510 PMCID: PMC3788140 SCOPUS ID: 2-s2.0-84885036837 10/08/2013 34 Citations

Protein structure in context: the molecular landscape of angiogenesis. (Span EA, Goodsell DS, Ramchandran R, Franzen MA, Herman T, Sem DS) Biochem Mol Biol Educ 2013;41(4):213-23 PMID: 23868376 PMCID: PMC4074543 SCOPUS ID: 2-s2.0-84880596856 07/23/2013 7 Citations

Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. (Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA) J Biol Chem 2013 Apr 12;288(15):10265-74 PMID: 23393131 PMCID: PMC3624410 SCOPUS ID: 2-s2.0-84876229992 02/09/2013 13 Citations

Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries. (Wickramasekera NT, Gebremedhin D, Carver KA, Vakeel P, Ramchandran R, Schuett A, Harder DR) J Appl Physiol (1985) 2013 Jan 15;114(2):252-61 PMID: 23172031 PMCID: PMC3544499 SCOPUS ID: 2-s2.0-84872285379 11/23/2012 9 Citations

Studies on Axenfeld-Rieger syndrome patients and mice reveal Foxc1's role in corneal neovascularization. (François M, Ramchandran R) Proc Natl Acad Sci U S A 2012 Feb 07;109(6):1818-9 PMID: 22308435 PMCID: PMC3277551 SCOPUS ID: 2-s2.0-84857136076 02/07/2012 3 Citations

Reactive oxygen species driven angiogenesis by inorganic nanorods. (Patra CR, Kim JH, Pramanik K, d'Uscio LV, Patra S, Pal K, Ramchandran R, Strano MS, Mukhopadhyay D) Nano Lett 2011 Nov 09;11(11):4932-8 PMID: 21967244 PMCID: PMC3212653 SCOPUS ID: 2-s2.0-80755142772 10/05/2011 75 Citations

Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. (Samant GV, Schupp MO, François M, Moleri S, Kothinti RK, Chun CZ, Sinha I, Sellars S, Leigh N, Pramanik K, Horswill MA, Remadevi I, Li K, Wilkinson GA, Tabatabai NM, Beltrame M, Koopman P, Ramchandran R) J Biol Chem 2011 Sep 02;286(35):30740-30747 PMID: 21730073 PMCID: PMC3162435 SCOPUS ID: 2-s2.0-80052229773 07/07/2011 14 Citations

Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. (Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M) Blood 2011 Aug 18;118(7):2015-26 PMID: 21636859 PMCID: PMC3158727 SCOPUS ID: 2-s2.0-80051865329 06/04/2011 92 Citations

Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. (Chun CZ, Remadevi I, Schupp MO, Samant GV, Pramanik K, Wilkinson GA, Ramchandran R) PLoS One 2011 Feb 25;6(2):e14732 PMID: 21364913 PMCID: PMC3045372 SCOPUS ID: 2-s2.0-79952155685 03/03/2011 12 Citations

Natural antisense transcript: a concomitant engagement with protein-coding transcript. (Li K, Ramchandran R) Oncotarget 2010 Oct;1(6):447-52 PMID: 21311100 PMCID: PMC3248111 SCOPUS ID: 2-s2.0-79957523447 02/12/2011 51 Citations

Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway. (Zhao B, Chun C, Liu Z, Horswill MA, Pramanik K, Wilkinson GA, Ramchandran R, Miao RQ) Blood 2010 Dec 09;116(24):5423-33 PMID: 20813898 PMCID: PMC3012551 SCOPUS ID: 2-s2.0-78650050262 09/04/2010 46 Citations

Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. (Verma A, Bhattacharya R, Remadevi I, Li K, Pramanik K, Samant GV, Horswill M, Chun CZ, Zhao B, Wang E, Miao RQ, Mukhopadhyay D, Ramchandran R, Wilkinson GA) Blood 2010 Jun 03;115(22):4614-22 PMID: 20086248 PMCID: PMC2881497 SCOPUS ID: 2-s2.0-77953922296 01/21/2010 31 Citations

A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. (Li K, Blum Y, Verma A, Liu Z, Pramanik K, Leigh NR, Chun CZ, Samant GV, Zhao B, Garnaas MK, Horswill MA, Stanhope SA, North PE, Miao RQ, Wilkinson GA, Affolter M, Ramchandran R) Blood 2010 Jan 07;115(1):133-9 PMID: 19880500 PMCID: PMC2803688 SCOPUS ID: 2-s2.0-74949140605 11/03/2009 137 Citations

Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. (Jia Y, Wu SL, Isenberg JS, Dai S, Sipes JM, Field L, Zeng B, Bandle RW, Ridnour LA, Wink DA, Ramchandran R, Karger BL, Roberts DD) Cell Stress Chaperones 2010 Mar;15(2):165-81 PMID: 19579057 PMCID: PMC2866983 SCOPUS ID: 2-s2.0-77950366991 07/07/2009 40 Citations

Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. (Kanungo J, Zheng YL, Amin ND, Kaur S, Ramchandran R, Pant HC) Biochem Biophys Res Commun 2009 Aug 14;386(1):263-7 PMID: 19523926 PMCID: PMC2758157 SCOPUS ID: 2-s2.0-67649210729 06/16/2009 11 Citations

A whole-animal microplate assay for metabolic rate using zebrafish. (Makky K, Duvnjak P, Pramanik K, Ramchandran R, Mayer AN) J Biomol Screen 2008 Dec;13(10):960-7 PMID: 19029015 SCOPUS ID: 2-s2.0-58149389320 11/26/2008 17 Citations

Silencing of directional migration in roundabout4 knockdown endothelial cells. (Kaur S, Samant GV, Pramanik K, Loscombe PW, Pendrak ML, Roberts DD, Ramchandran R) BMC Cell Biol 2008 Nov 03;9:61 PMID: 18980679 PMCID: PMC2613885 SCOPUS ID: 2-s2.0-58149397961 11/05/2008 42 Citations

Dusp-5 and Snrk-1 coordinately function during vascular development and disease. (Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE, Ramchandran R) Blood 2009 Jan 29;113(5):1184-91 PMID: 18927432 PMCID: PMC2635084 SCOPUS ID: 2-s2.0-60849096090 10/18/2008 57 Citations

Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. (Garnaas MK, Moodie KL, Liu ML, Samant GV, Li K, Marx R, Baraban JM, Horowitz A, Ramchandran R) Circ Res 2008 Sep 26;103(7):710-6 PMID: 18757825 PMCID: PMC2758496 SCOPUS ID: 2-s2.0-54449100292 09/02/2008 54 Citations

Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. (Chun CZ, Kaur S, Samant GV, Wang L, Pramanik K, Garnaas MK, Li K, Field L, Mukhopadhyay D, Ramchandran R) Blood 2009 Jan 29;113(5):1192-9 PMID: 18723694 PMCID: PMC2635085 SCOPUS ID: 2-s2.0-59649109527 08/30/2008 28 Citations

Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development (Gene Expression 13, 6, (321-327)) (Kaur S, Abu-Asab MS, Singla S, Yeo SY, Ramchandran R) Gene Expression 2007;14(2):129 SCOPUS ID: 2-s2.0-38949187921 12/01/2007

Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development. (Kaur S, Abu-Asab MS, Singla S, Yeo SY, Ramchandran R) Gene Expr 2007;13(6):321-7 PMID: 17708418 PMCID: PMC2562791 SCOPUS ID: 2-s2.0-34548056740 08/22/2007 5 Citations

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid. (Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD) Br J Pharmacol 2007 May;151(1):63-72 PMID: 17351657 PMCID: PMC2012973 SCOPUS ID: 2-s2.0-34247595399 03/14/2007 73 Citations

Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. (Kanungo J, Li BS, Goswami M, Zheng YL, Ramchandran R, Pant HC) Neurosci Lett 2007 Feb 02;412(3):233-8 PMID: 17178437 PMCID: PMC2696171 SCOPUS ID: 2-s2.0-33846262166 12/21/2006 17 Citations

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. (Arbiser JL, Kau T, Konar M, Narra K, Ramchandran R, Summers SA, Vlahos CJ, Ye K, Perry BN, Matter W, Fischl A, Cook J, Silver PA, Bain J, Cohen P, Whitmire D, Furness S, Govindarajan B, Bowen JP) Blood 2007 Jan 15;109(2):560-5 PMID: 16990598 PMCID: PMC1785094 SCOPUS ID: 2-s2.0-33846231294 09/23/2006 85 Citations

A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. (Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP) J Cell Sci 2006 Oct 01;119(Pt 19):4117-26 PMID: 16968741 SCOPUS ID: 2-s2.0-33750448249 09/14/2006 59 Citations

Robo4 signaling in endothelial cells implies attraction guidance mechanisms. (Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R) J Biol Chem 2006 Apr 21;281(16):11347-56 PMID: 16481322 SCOPUS ID: 2-s2.0-33744952643 02/17/2006 77 Citations

roundabout4 is essential for angiogenesis in vivo. (Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R) Proc Natl Acad Sci U S A 2005 May 03;102(18):6373-8 PMID: 15849270 PMCID: PMC1088354 SCOPUS ID: 2-s2.0-20944450769 04/26/2005 190 Citations

Critical roles of CD146 in zebrafish vascular development. (Chan B, Sinha S, Cho D, Ramchandran R, Sukhatme VP) Dev Dyn 2005 Jan;232(1):232-44 PMID: 15580611 SCOPUS ID: 2-s2.0-11244290381 12/08/2004 50 Citations

Cellular actions and signaling by endostatin. (Ramchandran R, Karumanchi SA, Hanai J, Alper SL, Sukhatme VP) Crit Rev Eukaryot Gene Expr 2002;12(3):175-91 PMID: 12449342 PMCID: PMC3270378 SCOPUS ID: 2-s2.0-0037584218 11/27/2002 20 Citations

Endostatin is a potential inhibitor of Wnt signaling. (Hanai J, Gloy J, Karumanchi SA, Kale S, Tang J, Hu G, Chan B, Ramchandran R, Jha V, Sukhatme VP, Sokol S) J Cell Biol 2002 Aug 05;158(3):529-39 PMID: 12147676 PMCID: PMC2173844 SCOPUS ID: 2-s2.0-0036324664 07/31/2002 145 Citations

Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. (Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP) J Biol Chem 2002 May 10;277(19):16464-9 PMID: 11815623 SCOPUS ID: 2-s2.0-0037052336 01/30/2002 219 Citations

Cell surface glypicans are low-affinity endostatin receptors. (Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP) Mol Cell 2001 Apr;7(4):811-22 PMID: 11336704 SCOPUS ID: 2-s2.0-0035021908 05/05/2001 274 Citations

Antitumor interaction of short-course endostatin and ionizing radiation. (Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR) Cancer J 2000;6(5):287-93 PMID: 11079167 SCOPUS ID: 2-s2.0-0033758044 11/18/2000 61 Citations

A (GATA)(7) motif located in the 5' boundary area of the human beta-globin locus control region exhibits silencer activity in erythroid cells. (Ramchandran R, Bengra C, Whitney B, Lanclos K, Tuan D) Am J Hematol 2000 Sep;65(1):14-24 PMID: 10936858 SCOPUS ID: 2-s2.0-0033839103 08/11/2000 18 Citations

Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. (Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme VP, Kalluri R) J Biol Chem 2000 Jan 14;275(2):1209-15 PMID: 10625665 SCOPUS ID: 2-s2.0-0033979905 01/08/2000 415 Citations

Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. (Lu H, Dhanabal M, Volk R, Waterman MJ, Ramchandran R, Knebelmann B, Segal M, Sukhatme VP) Biochem Biophys Res Commun 1999 May 19;258(3):668-73 PMID: 10329443 SCOPUS ID: 2-s2.0-0033583830 05/18/1999 73 Citations

Cloning, expression, and in vitro activity of human endostatin. (Dhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme VP) Biochem Biophys Res Commun 1999 May 10;258(2):345-52 PMID: 10329390 SCOPUS ID: 2-s2.0-0033542129 05/18/1999 199 Citations

Endostatin induces endothelial cell apoptosis. (Dhanabal M, Ramchandran R, Waterman MJ, Lu H, Knebelmann B, Segal M, Sukhatme VP) J Biol Chem 1999 Apr 23;274(17):11721-6 PMID: 10206987 SCOPUS ID: 2-s2.0-0033597130 04/17/1999 592 Citations

Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. (Ramchandran R, Dhanabal M, Volk R, Waterman MJ, Segal M, Lu H, Knebelmann B, Sukhatme VP) Biochem Biophys Res Commun 1999 Feb 24;255(3):735-9 PMID: 10049780 SCOPUS ID: 2-s2.0-0033599308 03/02/1999 253 Citations

Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma. (Dhanabal M, Ramchandran R, Volk R, Stillman IE, Lombardo M, Iruela-Arispe ML, Simons M, Sukhatme VP) Cancer Res 1999 Jan 01;59(1):189-97 PMID: 9892206 SCOPUS ID: 2-s2.0-0032894131 01/19/1999 259 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Ramani Ramchandran PhD

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Publications (107)