Faculty Collaboration Database

Interleukin 4/13 signaling in cardiac regeneration and repair. Am J Physiol Heart Circ Physiol 2022 Nov 01;323(5):H833-H844

Date

09/24/2022

Pubmed ID

36149768

Pubmed Central ID

PMC9602781

DOI

10.1152/ajpheart.00310.2022

Scopus ID

2-s2.0-85140273361 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Interleukin 4 (IL4) and interleukin 13 (IL13) are closely related cytokines that have been classically attributed to type II immunity, namely, differentiation of T-helper 2 (T_H2) cells and alternative activation of macrophages. Although the role of IL4/13 has been well described in various contexts such as defense against helminth parasites, pathogenesis of allergic disease, and several models of wound healing, relatively little is known about the role of IL4/13 in the heart following injury. Emerging literature has identified various roles for IL4/13 in animal models of cardiac regeneration as well as in the adult mammalian heart following myocardial injury. Notably, although IL4 and IL13 signal to hematopoietic cell types following myocardial infarction (MI) to promote wound healing phenotypes, there is substantial evidence that these cytokines can signal directly to non-hematopoietic cell types in the heart during development, homeostasis, and following injury. Comprehensive understanding of the molecular and cellular actions of IL4/13 in the heart is still lacking, but overall evidence to date suggests that activation of these cytokines results in beneficial outcomes with respect to cardiac repair. Here, we aim to comprehensively review the role of IL4 and IL13 and their prospective mechanisms in cardiac regeneration and repair.

Author List

Bakhshian Nik A, Alvarez-Argote S, O'Meara CC

Authors

Amirala Bakhshiannik Postdoctoral Fellow in the Physiology department at Medical College of Wisconsin
Caitlin C. O'Meara PhD Associate Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cytokines
Heart
Interleukin-13
Interleukin-4
Mammals
Regeneration