Intermittent cold exposure enhances fat accumulation in mice. PLoS One 2014;9(5):e96432
Date
05/03/2014Pubmed ID
24789228Pubmed Central ID
PMC4008632DOI
10.1371/journal.pone.0096432Scopus ID
2-s2.0-84900441565 (requires institutional sign-in at Scopus site) 30 CitationsAbstract
Due to its high energy consuming characteristics, brown adipose tissue (BAT) has been suggested as a key player in energy metabolism. Cold exposure is a physiological activator of BAT. Intermittent cold exposure (ICE), unlike persistent exposure, is clinically feasible. The main objective of this study was to investigate whether ICE reduces adiposity in C57BL/6 mice. Surprisingly, we found that ICE actually increased adiposity despite enhancing Ucp1 expression in BAT and inducing beige adipocytes in subcutaneous white adipose tissue. ICE did not alter basal systemic insulin sensitivity, but it increased liver triglyceride content and secretion rate as well as blood triglyceride levels. Gene profiling further demonstrated that ICE, despite suppressing lipogenic gene expression in white adipose tissue and liver during cold exposure, enhanced lipogenesis between the exposure periods. Together, our results indicate that despite enhancing BAT recruitment, ICE in mice increases fat accumulation by stimulating de novo lipogenesis.
Author List
Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao JAuthor
Nikki K. Lytle PhD Assistant Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdipocytesAdipose Tissue, Brown
Adiposity
Analysis of Variance
Animals
Cold Temperature
Eating
Energy Metabolism
Gene Expression Profiling
Immunoblotting
Insulin Resistance
Ion Channels
Lipogenesis
Liver
Mice, Inbred C57BL
Mitochondrial Proteins
Reverse Transcriptase Polymerase Chain Reaction
Subcutaneous Fat
Time Factors
Triglycerides
Uncoupling Protein 1
