Medical College of Wisconsin
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Nikki K. Lytle PhD

Nikki K. Lytle PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Surgical Oncology

Member of the Cancer Center


I am willing to collaborate on research projects.
I am willing to be a peer mentor.

View Curriculum Vitae

Research Experience

  • Breast Neoplasms
  • CRISPR-Cas Systems
  • Carcinoma, Pancreatic Ductal
  • Cell Plasticity
  • Cell Transformation, Neoplastic
  • Chromatin
  • Disease Models, Animal
  • Epigenesis, Genetic
  • Flow Cytometry
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Histology
  • Organoids
  • Single-Cell Analysis
  • Transcription Factors
  • Patient-Derived Xenografts

    • Publications (25)

  • Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. (Rajbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schürch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, Wen KW, Tsai S, Goggins MG, Lowy AM, Wechsler-Reya RJ, Von Hoff DD, Newman AM, Reya T) Cancer Cell 2023 Nov 13;41(11):1989-2005.e9 PMID: 37802055 PMCID: PMC10836835 SCOPUS ID: 2-s2.0-85174675997 10/07/2023       1 Citation
  • Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. (Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schürch CM, Puri PL, Bruneau BG, Hargreaves DC, Reya T) Nat Commun 2023 Jan 18;14(1):292 PMID: 36653361 PMCID: PMC9849267 SCOPUS ID: 2-s2.0-85146485571 01/19/2023       4 Citations
  • Eicosanoids in the pancreatic tumor microenvironment - a multicellular, multifaceted progression. (Gubbala VB, Jytosana N, Trinh VQ, Maurer HC, Naeem RF, Lytle NK, Ma Z, Zhao S, Lin W, Han H, Shi Y, Hunter T, Singh PK, Olive KP, Tan MCB, Kaech SM, Wahl GM, DelGiorno KE) Gastro Hep Adv 2022;1(4):682-697 PMID: 36277993 PMCID: PMC9583893 SCOPUS ID: 2-s2.0-85144987357 10/25/2022       4 Citations
  • Single-Cell Transcriptomic and Epigenetic Analyses of Mouse Mammary Development Starting with the Embryo. (Ma Z, Lytle NK, Ramos C, Naeem RF, Wahl GM) Methods Mol Biol 2022;2471:49-82 PMID: 35175591 PMCID: PMC9663269 SCOPUS ID: 2-s2.0-85124776790 02/18/2022    
  • Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T) Nature 2021 Dec;600(7889):E18 PMID: 34848876 SCOPUS ID: 2-s2.0-85120323893 12/02/2021       3 Citations
  • Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury. (Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE) Gastroenterology 2022 Feb;162(2):604-620.e20 PMID: 34695382 PMCID: PMC8792222 SCOPUS ID: 2-s2.0-85122247341 10/26/2021       34 Citations
  • A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia. (Spinler K, Bajaj J, Ito T, Zimdahl B, Hamilton M, Ahmadi A, Koechlein CS, Lytle N, Kwon HY, Anower-E-Khuda F, Sun H, Blevins A, Weeks J, Kritzik M, Karlseder J, Ginsberg MH, Park PW, Esko JD, Reya T) Nat Commun 2020 Nov 26;11(1):5998 PMID: 33243988 PMCID: PMC7691523 SCOPUS ID: 2-s2.0-85096693573 11/28/2020       9 Citations
  • Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. (DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM) Gastroenterology 2020 Nov;159(5):1866-1881.e8 PMID: 32717220 PMCID: PMC7680354 SCOPUS ID: 2-s2.0-85089702914 07/28/2020       37 Citations
  • Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders. (Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC Jr, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM) Proc Natl Acad Sci U S A 2020 Jun 02;117(22):12121-12130 PMID: 32424096 PMCID: PMC7275768 SCOPUS ID: 2-s2.0-85085904273 05/20/2020       11 Citations
  • Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury. (Lusardi TA, Lytle NK, Gebril HM, Boison D) J Caffeine Adenosine Res 2020 Mar 01;10(1):12-24 PMID: 32181443 PMCID: PMC7071069 03/18/2020    
  • Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. (Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW) Life Sci Alliance 2020 Jan;3(1) PMID: 31959624 PMCID: PMC6971368 SCOPUS ID: 2-s2.0-85078632811 01/22/2020       31 Citations
  • Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T) Nature 2019 May;569(7754):131-135 PMID: 30996350 PMCID: PMC6565370 SCOPUS ID: 2-s2.0-85064686834 04/19/2019       267 Citations
  • A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. (Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T) Cell 2019 Apr 18;177(3):572-586.e22 PMID: 30955884 PMCID: PMC6711371 SCOPUS ID: 2-s2.0-85064184859 04/09/2019       100 Citations
  • Stem cell fate in cancer growth, progression and therapy resistance. (Lytle NK, Barber AG, Reya T) Nat Rev Cancer 2018 Nov;18(11):669-680 PMID: 30228301 PMCID: PMC8388042 SCOPUS ID: 2-s2.0-85053790127 09/20/2018       436 Citations
  • Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. (Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM) Cancer Cell 2018 Sep 10;34(3):466-482.e6 PMID: 30174241 PMCID: PMC6152943 SCOPUS ID: 2-s2.0-85053923084 09/04/2018       90 Citations
  • Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. (Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M) Cancer Cell 2017 Dec 11;32(6):824-839.e8 PMID: 29153842 PMCID: PMC5730340 SCOPUS ID: 2-s2.0-85034422866 11/21/2017       96 Citations
  • CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. (Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T) Cancer Cell 2016 Nov 14;30(5):792-805 PMID: 27908736 PMCID: PMC5137811 SCOPUS ID: 2-s2.0-85006041197 12/03/2016       77 Citations
  • Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. (Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T) Nature 2016 Jun 16;534(7607):407-411 PMID: 27281208 PMCID: PMC4998062 SCOPUS ID: 2-s2.0-84976328190 06/10/2016       108 Citations
  • Glycine transporter 1 is a target for the treatment of epilepsy. (Shen HY, van Vliet EA, Bright KA, Hanthorn M, Lytle NK, Gorter J, Aronica E, Boison D) Neuropharmacology 2015 Dec;99:554-65 PMID: 26302655 PMCID: PMC4655139 SCOPUS ID: 2-s2.0-84940567617 08/26/2015       37 Citations
  • Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. (Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T) Cell Stem Cell 2015 Aug 06;17(2):152-164 PMID: 26212080 PMCID: PMC4664079 SCOPUS ID: 2-s2.0-84938741455 07/28/2015       56 Citations
  • Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. (Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M) Proc Natl Acad Sci U S A 2014 Sep 23;111(38):13870-5 PMID: 25189770 PMCID: PMC4183333 SCOPUS ID: 2-s2.0-84907284168 09/06/2014       83 Citations
  • Intermittent cold exposure enhances fat accumulation in mice. (Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J) PLoS One 2014;9(5):e96432 PMID: 24789228 PMCID: PMC4008632 SCOPUS ID: 2-s2.0-84900441565 05/03/2014       27 Citations
  • Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. (Williams-Karnesky RL, Sandau US, Lusardi TA, Lytle NK, Farrell JM, Pritchard EM, Kaplan DL, Boison D) J Clin Invest 2013 Aug;123(8):3552-63 PMID: 23863710 PMCID: PMC3726154 SCOPUS ID: 2-s2.0-84879710932 07/19/2013       198 Citations
  • The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. (Duncan JE, Lytle NK, Zuniga A, Goldstein LS) PLoS One 2013;8(6):e68324 PMID: 23840848 PMCID: PMC3694009 SCOPUS ID: 2-s2.0-84879477553 07/11/2013       39 Citations
  • Caffeine prevents acute mortality after TBI in rats without increased morbidity. (Lusardi TA, Lytle NK, Szybala C, Boison D) Exp Neurol 2012 Mar;234(1):161-8 PMID: 22226594 PMCID: PMC3294054 SCOPUS ID: 2-s2.0-84857502482 01/10/2012       38 Citations
    • Last update: 10/07/2023