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Abnormal cerebral activation associated with a motor task in Tourette syndrome. AJNR Am J Neuroradiol 1998 Sep;19(8):1509-12

Date

10/08/1998

Pubmed ID

9763386

Pubmed Central ID

PMC8338689

Scopus ID

2-s2.0-0032231694   82 Citations

Abstract

BACKGROUND AND PURPOSE: In Gilles de la Tourette syndrome, PET scanning and EEG suggest an abnormal organization of the sensorimotor cortex and basal ganglia. The purpose of this study was to use functional MR imaging to study activation in the sensorimotor cortex in patients with Tourette syndrome.

METHODS: From echo-planar images acquired during intermittent performance of a finger-tapping task, the location of activated pixels was determined by means of conventional signal processing methods. In five patients with Tourette syndrome and five healthy volunteers, the number of activated pixels in the sensorimotor cortices and supplementary motor areas were counted. The area over which the activation was distributed was calculated.

RESULTS: In the five patients, the average number of pixels activated during the finger-tapping task in the sensorimoter cortices and supplementary motor area (69.4 pixels) exceeded that in the volunteers (49.2 pixels). The difference was significant. The area over which the pixels was distributed was significantly larger (25.4 vs 13.8 cm2).

CONCLUSION: Motor function is organized differently in patients with Tourette syndrome than in healthy subjects.

Author List

Biswal B, Ulmer JL, Krippendorf RL, Harsch HH, Daniels DL, Hyde JS, Haughton VM

Author

Harold H. Harsch MD Professor in the Psychiatry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Arousal
Diseases in Twins
Echo-Planar Imaging
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Motor Activity
Motor Cortex
Somatosensory Cortex
Tourette Syndrome