Relationship between cognitive reserve, brain volume, and neuropsychological performance in amnestic and nonamnestic MCI. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2023;30(6):940-956
Date
12/28/2022Pubmed ID
36573001DOI
10.1080/13825585.2022.2161462Scopus ID
2-s2.0-85145338983 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Cognitive Reserve (CR) is a theoretical construct that influences the onset and course of cognitive and structural changes that occur with aging and mild cognitive impairment (MCI). There is a paucity of research that examines the relationship of CR and brain volumes in amnestic (aMCI) and nonamnestic (naMCI) separately. This study is a retrospective chart review of MCI patients who underwent neuropsychological evaluation and brain MRI with NeuroReader™ (NR). NR is an FDA-cleared software that standardizes MRI volumes to a control sample. Classifications of aMCI and naMCI were based on Petersen criteria. CR was measured as education, occupation, and word reading. Data analysis included bivariate correlations between CR, neuropsychological test scores, and NR-brain volumes by MCI subtype. The Benjamini-Hochberg method corrected for multiple comparisons. The sample included 91 participants with aMCI and 41 with naMCI. Within naMCI, positive correlations were observed between CR and whole brain volume, total gray matter, bifrontal, left parietal, left occipital, and bilateral cerebellum. Within aMCI, no significant correlations were observed between CR and brain volumes. Positive correlations with CR were observed in language, attention, and visual learning in both aMCI and naMCI groups. The current study adds to the minimal literature on CR and naMCI. Results revealed that CR is associated with volumetrics in naMCI only, though cognitive findings were similar in both MCI groups. Possible explanations include heterogeneous disease pathologies, disease stage, or a differential influence of CR on volumetrics in MCI. Additional longitudinal and biomarker studies will better elucidate this relationship.
Author List
Reiter K, Butts AM, Janecek JK, Correro AN, Nencka A, Agarwal M, Franczak M, Glass Umfleet LAuthors
Mohit Agarwal MD Associate Professor in the Radiology department at Medical College of WisconsinAlissa Butts PhD Associate Professor in the Neurology department at Medical College of Wisconsin
Anthony N. Correro PhD Assistant Professor in the Neurology department at Medical College of Wisconsin
Malgorzata Franczak MD Professor in the Neurology department at Medical College of Wisconsin
Julie K. Janecek PhD Associate Professor in the Neurology department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin
Laura Umfleet PsyD Associate Professor in the Neurology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AmnesiaBrain
Cognitive Dysfunction
Cognitive Reserve
Humans
Neuropsychological Tests
Retrospective Studies
