Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein oxidation. Methods Enzymol 1999;301:444-53
Date
01/27/1999Pubmed ID
9919593DOI
10.1016/s0076-6879(99)01108-8Scopus ID
2-s2.0-0031795335 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
Nitric oxide, when slowly released from a donor compound, has a potent inhibitory effect on the oxidative modification of LDL. This can be studied by monitoring changes in the lipid, protein, and antioxidant components of the LDL particle. In addition, the kinetics of LDL oxidation provides an insight into the mechanistic basis of the nitric oxide-dependent inhibition of LDL oxidation.
Author List
Goss SP, Kalyanaraman B, Hogg NAuthors
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinBalaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsAntioxidants
Humans
Lipid Peroxidation
Lipoproteins, LDL
Nitric Oxide
Nitric Oxide Donors