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Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein oxidation. Methods Enzymol 1999;301:444-53

Date

01/27/1999

Pubmed ID

9919593

DOI

10.1016/s0076-6879(99)01108-8

Scopus ID

2-s2.0-0031795335 (requires institutional sign-in at Scopus site)   24 Citations

Abstract

Nitric oxide, when slowly released from a donor compound, has a potent inhibitory effect on the oxidative modification of LDL. This can be studied by monitoring changes in the lipid, protein, and antioxidant components of the LDL particle. In addition, the kinetics of LDL oxidation provides an insight into the mechanistic basis of the nitric oxide-dependent inhibition of LDL oxidation.

Author List

Goss SP, Kalyanaraman B, Hogg N

Authors

Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of Wisconsin
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Antioxidants
Humans
Lipid Peroxidation
Lipoproteins, LDL
Nitric Oxide
Nitric Oxide Donors