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Multi-shell connectome DWI-based graph theory measures for the prediction of temporal lobe epilepsy and cognition. Cereb Cortex 2023 Jun 08;33(12):8056-8065

Date

04/18/2023

Pubmed ID

37067514

Pubmed Central ID

PMC10267614

DOI

10.1093/cercor/bhad098

Scopus ID

2-s2.0-85163480791 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Temporal lobe epilepsy (TLE) is the most common epilepsy syndrome that empirically represents a network disorder, which makes graph theory (GT) a practical approach to understand it. Multi-shell diffusion-weighted imaging (DWI) was obtained from 89 TLE and 50 controls. GT measures extracted from harmonized DWI matrices were used as factors in a support vector machine (SVM) analysis to discriminate between groups, and in a k-means algorithm to find intrinsic structural phenotypes within TLE. SVM was able to predict group membership (mean accuracy = 0.70, area under the curve (AUC) = 0.747, Brier score (BS) = 0.264) using 10-fold cross-validation. In addition, k-means clustering identified 2 TLE clusters: 1 similar to controls, and 1 dissimilar. Clusters were significantly different in their distribution of cognitive phenotypes, with the Dissimilar cluster containing the majority of TLE with cognitive impairment (χ2 = 6.641, P = 0.036). In addition, cluster membership showed significant correlations between GT measures and clinical variables. Given that SVM classification seemed driven by the Dissimilar cluster, SVM analysis was repeated to classify Dissimilar versus Similar + Controls with a mean accuracy of 0.91 (AUC = 0.957, BS = 0.189). Altogether, the pattern of results shows that GT measures based on connectome DWI could be significant factors in the search for clinical and neurobehavioral biomarkers in TLE.

Author List

Garcia-Ramos C, Adluru N, Chu DY, Nair V, Adluru A, Nencka A, Maganti R, Mathis J, Conant LL, Alexander AL, Prabhakaran V, Binder JR, Meyerand ME, Hermann B, Struck AF

Authors

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin
Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cognition
Connectome
Diffusion Magnetic Resonance Imaging
Epilepsy, Temporal Lobe
Humans
Magnetic Resonance Imaging