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Whole Genome Sequence of a Treponema pallidum Strain From a Formalin-Fixed, Paraffin-Embedded Fine Needle Aspirate of a Cervical Lymph Node. Sex Transm Dis 2023 Aug 01;50(8):550-552

Date

05/11/2023

Pubmed ID

37165832

Pubmed Central ID

PMC10524489

DOI

10.1097/OLQ.0000000000001827

Scopus ID

2-s2.0-85164282926 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

A patient with unilateral cervical lymphadenopathy suspicious for malignancy underwent a fine needle aspiration. Histology demonstrated mixed inflammatory infiltrates with abundant spirochetes. Sufficient spirochete DNA was extracted from paraffin-embedded tissue sections to obtain the near-complete genome sequence of a macrolide-resistant strain belonging to the SS14 omega strain of Treponema pallidum .

Author List

Aldrete S, Kroft SH, Romeis E, Lieberman NAP, Greninger AL, Giacani L, Kron MA

Authors

Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of Wisconsin
Michael Kron MD Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Biopsy, Fine-Needle
Formaldehyde
Humans
Lymph Nodes
Paraffin Embedding
Treponema pallidum