Subgenual cingulate connectivity in children with a history of preschool-depression. Neuroreport 2010 Dec 29;21(18):1182-8
Date
11/05/2010Pubmed ID
21048519Pubmed Central ID
PMC3008372DOI
10.1097/WNR.0b013e32834127ebScopus ID
2-s2.0-78650510826 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
The subgenual anterior cingulate cortex (sgACC) presents altered functional connections with other regions of the brain in individuals with depression. However, the developmental nature of this phenomenon remains largely unexplored. Functional connections of the sgACC were examined in 36 school age children, 17 with a history of preschool onset major depressive disorder (PO-MDD). The sgACC exhibited increased connections with cognitive control regions in healthy children and increased connections with thalamic and parietal regions in the PO-MDD group. A significant correlation between dysregulated emotional behavior and connectivity of the sgACC and dorsal medial prefrontal cortex was also found. These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression.
Author List
Gaffrey MS, Luby JL, Repovš G, Belden AC, Botteron KN, Luking KR, Barch DMAuthor
Michael S. Gaffrey PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingBrain Mapping
Child
Corpus Callosum
Depressive Disorder
Female
Gyrus Cinguli
Humans
Magnetic Resonance Imaging
Male
Neural Pathways
Neuropsychological Tests
