New perspectives on sex differences in learning and memory. Trends Endocrinol Metab 2023 Sep;34(9):526-538
Date
07/28/2023Pubmed ID
37500421Pubmed Central ID
PMC10617789DOI
10.1016/j.tem.2023.06.003Scopus ID
2-s2.0-85165648763 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Females have historically been disregarded in memory research, including the thousands of studies examining roles for the hippocampus, medial prefrontal cortex, and amygdala in learning and memory. Even when included, females are often judged based on male-centric behavioral and neurobiological standards, generating and perpetuating scientific stereotypes that females exhibit worse memories compared with males in domains such as spatial navigation and fear. Recent research challenges these dogmas by identifying sex-specific strategies in common memory tasks. Here, we discuss rodent data illustrating sex differences in spatial and fear memory, as well as the neural mechanisms underlying memory formation. The influence of sex steroid hormones in both sexes is discussed, as is the importance to basic and translational neuroscience of studying sex differences.
Author List
Fleischer AW, Frick KMAuthor
Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AnimalsFemale
Gonadal Steroid Hormones
Hippocampus
Learning
Male
Sex Characteristics
