Faculty Collaboration Database

Pulmonary disposition of lipophilic amine compounds in the isolated perfused rabbit lung. J Appl Physiol (1985) 1998 Feb;84(2):516-30

Date

02/26/1998

Pubmed ID

9475861

DOI

10.1152/jappl.1998.84.2.516

Scopus ID

2-s2.0-0031938725 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

We measured the pulmonary venous concentration vs. time curves for [3H]alfentanil, [14C]lidocaine, and [3H]codeine after the bolus injection of each of these lipophilic amine compounds (LAC) and a vascular-reference indicator (fluorescein isothiocyanate-dextran) into the pulmonary artery of isolated perfused rabbit lungs. A range of flows and perfusate albumin concentrations was studied. To evaluate the information content of the data, we developed a kinetic model describing the pulmonary disposition of these LAC that was based on indicator dilution theory, and we sought a robust approach for interpreting the estimated model parameters. We found that the distribution of the kinetic model rate constants of the lipophilic amine-tissue interactions can be described by alpha, H, and psi, where alpha is a measure of the capacity of the rapidly equilibrating interactions between the lipophilic amine and the tissue; H is a measure of the equilibrium capacity of the slowly equilibrating interactions between the lipophilic amine and the tissue; and psi is the mean sojourn time. The values of alpha, H, and psi were 0.8 +/- 0.1 (SE), 0.6 +/- 0.1, and 1.6 +/- 0.5 s; 1.9 +/- 0.1, 5.3 +/- 0.4, and 5.6 +/- 0.5 s; and 1.1 +/- 0.1, 9.8 +/- 0.4, and 4.7 +/- 0.2 s for alfentanil, lidocaine, and codeine, respectively. These values for alpha, H, and psi reveal the relative dominance of the slowly equilibrating interactions for lidocaine and codeine in comparison with alfentanil. This approach to data analysis may have utility for the potential use of LAC to reveal and to quantify changes in lung tissue composition associated with lung disease.

Author List

Audi SH, Dawson CA, Linehan JH, Krenz GS, Ahlf SB, Roerig DL

Author

Said Audi PhD Professor in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Alfentanil
Animals
Codeine
Female
In Vitro Techniques
Indicator Dilution Techniques
Injections, Intra-Arterial
Lidocaine
Lung
Male
Models, Biological
Perfusion
Pulmonary Artery
Rabbits
Serum Albumin, Bovine
Tissue Distribution