Faculty Collaboration Database

Histopathological evaluation of orchiectomy specimens in 51 late postpubertal men with unilateral cryptorchidism. J Urol 2014 Oct;192(4):1183-8

Date

05/21/2014

Pubmed ID

24840535

DOI

10.1016/j.juro.2014.05.048

Scopus ID

2-s2.0-84921967750 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

PURPOSE: We evaluate the histopathological features of uncorrected undescended testis presenting at a late postpubertal age.

MATERIALS AND METHODS: The study included 51 men (age 20 to 24 years) diagnosed with inguinal unilateral undescended testis found on routine examination for military recruits. None was evaluated or treated for undescended testis previously. All of the men had a normal contralateral testis and no other observed phenotypic alterations, and all had undergone unilateral orchiectomy. The surgical specimens were first examined histologically, and sections were additionally examined with immunohistochemical methods using antibodies against CD117 and OCT3/4 proteins to verify the presence of intratubular germ cell neoplasia.

RESULTS: Histopathology revealed the presence of germ cells at different maturation levels in 26 of 51 (51%) cases. There were 28 cases (55%) with different degrees of basal membrane thickening. A decrease in seminiferous tubule diameter was observed in 23 (45%) patients. Six patients (12%) had dystrophic calcification and 12 (24%) had Leydig cell hyperplasia. Although morphological evaluation did not show intratubular germ cell neoplasia in any patients, 1 with germ cells had positivity for OCT3/4 and CD117 staining. Therefore, 1 case out of 51 had diagnosed intratubular germ cell neoplasia.

CONCLUSIONS: There was a wide range of histopathological changes in undescended testis. Nearly half the patients may still have significant germ cell activity at a variety of maturation levels. The incidence of intratubular germ cell neoplasia was 2% in this group. Intratubular germ cell neoplasia may be overlooked with hematoxylin and eosin staining so immunohistochemical study should be added for evaluation.

Author List

Koni A, Ozseker HS, Arpali E, Kilinc E, Dogan HS, Akyol A, Tekgul S

Author

Emre Arpali MD, PhD Associate Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cryptorchidism
Follow-Up Studies
Humans
Immunohistochemistry
Male
Military Personnel
Octamer Transcription Factor-3
Orchiectomy
Organic Cation Transport Proteins
Proto-Oncogene Proteins c-kit
Testis
Time Factors
Young Adult