Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav 1996 Jun;54(2):501-8
Date
06/01/1996Pubmed ID
8743615DOI
10.1016/0091-3057(95)02278-3Scopus ID
2-s2.0-0030001409 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
A crossover, double-blind trial was conducted using eleven healthy volunteers to determine whether and the degree to which acute drug tolerance occurred to the subjective, cognitive, and psychomotor effects of a range of subanesthetic nitrous oxide doses (0, 10, 20, 30, and 40%). There was little evidence of acute drug tolerance to the subjective measures or to the cognitive/psychomotor impairing effects of nitrous oxide at any of the concentrations tested over the course of the 120-min inhalation.
Author List
Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JLAuthor
Santosh Yajnik MD Associate Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Administration, InhalationAdult
Affect
Anesthetics, Inhalation
Cognition
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Drug Tolerance
Female
Hemodynamics
Humans
Male
Nitrous Oxide
Oxygen
Psychomotor Performance
