The acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and psychomotor performance in healthy volunteers. Anesth Analg 1996 Jan;82(1):153-7
Date
01/01/1996Pubmed ID
8712393DOI
10.1097/00000539-199601000-00028Scopus ID
2-s2.0-0030027406 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
A blind, randomized, cross-over trial was conducted to determine the degree of psychomotor/cognitive impairment and the recovery profile produced by combinations of subanesthetic concentrations of isoflurane and nitrous oxide in healthy volunteers. In the experiment, subjects (n = 10) inhaled 100% oxygen-placebo, 30% nitrous oxide in oxygen, and 0.2% and 0.4% isoflurane in oxygen, alone, and in combination with 30% nitrous oxide, in different sessions. Dependent measures included psychomotor and cognitive performance. Impairment was profound with the combination of inhaled anesthetics, and from an analysis of control conditions (the anesthetics alone), it appeared that isoflurane produced more impairment than did nitrous oxide. The time course of recovery was extremely rapid, with subjects returning to control-level functioning 5 min after cessation of the drug inhalation. The drug combination of isoflurane and nitrous oxide appears to be a promising candidate for conscious sedation procedures, although its analgesic and mood-altering effects need to be studied more systematically.
Author List
Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JLAuthor
Santosh Yajnik MD Associate Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAnesthetics, Inhalation
Cognition
Cognition Disorders
Cross-Over Studies
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Humans
Isoflurane
Male
Nitrous Oxide
Psychomotor Disorders
Psychomotor Performance
Single-Blind Method
