Clot or Not? Reviewing the Reciprocal Regulation Between Lipids and Blood Clotting. Arterioscler Thromb Vasc Biol 2024 Mar;44(3):533-544
Date
01/18/2024Pubmed ID
38235555Pubmed Central ID
PMC10922732DOI
10.1161/ATVBAHA.123.318286Scopus ID
2-s2.0-85185252234 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Both hyperlipidemia and thrombosis contribute to the risks of atherosclerotic cardiovascular diseases, which are the leading cause of death and reduced quality of life in survivors worldwide. The accumulation of lipid-rich plaques on arterial walls eventually leads to the rupture or erosion of vulnerable lesions, triggering excessive blood clotting and leading to adverse thrombotic events. Lipoproteins are highly dynamic particles that circulate in blood, carry insoluble lipids, and are associated with proteins, many of which are involved in blood clotting. A growing body of evidence suggests a reciprocal regulatory relationship between blood clotting and lipid metabolism. In this review article, we summarize the observations that lipoproteins and lipids impact the hemostatic system, and the clotting-related proteins influence lipid metabolism. We also highlight the gaps that need to be filled in this area of research.
Author List
Zhang Z, Rodriguez M, Zheng ZAuthor
Ze Zheng PhD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AtherosclerosisBlood Coagulation
Blood Coagulation Factors
Fibrinolysis
Humans
Lipoproteins
Quality of Life
Thrombosis
