Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 1998 Aug 07;94(3):299-305
Date
08/26/1998Pubmed ID
9708732DOI
10.1016/s0092-8674(00)81473-7Scopus ID
2-s2.0-0032493866 (requires institutional sign-in at Scopus site) 334 CitationsAbstract
Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid-type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of Pitx2 in the chick. Our results indicate that a common pathway from lefty-1 to Pitx2 likely exists for determination of L-R asymmetry in vertebrates.
Author List
Yoshioka H, Meno C, Koshiba K, Sugihara M, Itoh H, Ishimaru Y, Inoue T, Ohuchi H, Semina EV, Murray JC, Hamada H, Noji SAuthor
Elena V. Semina PhD Chief, Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBody Patterning
Chick Embryo
Drosophila Proteins
Embryo, Mammalian
Gene Expression Regulation, Developmental
Genes, Homeobox
Hedgehog Proteins
Homeodomain Proteins
Left-Right Determination Factors
Mice
Models, Genetic
Nuclear Proteins
Paired Box Transcription Factors
Protein Biosynthesis
Proteins
Signal Transduction
Trans-Activators
Transcription Factors
Transforming Growth Factor beta