Medical College of Wisconsin
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Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 1998 Aug 07;94(3):299-305

Date

08/26/1998

Pubmed ID

9708732

DOI

10.1016/s0092-8674(00)81473-7

Scopus ID

2-s2.0-0032493866 (requires institutional sign-in at Scopus site)   334 Citations

Abstract

Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid-type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of Pitx2 in the chick. Our results indicate that a common pathway from lefty-1 to Pitx2 likely exists for determination of L-R asymmetry in vertebrates.

Author List

Yoshioka H, Meno C, Koshiba K, Sugihara M, Itoh H, Ishimaru Y, Inoue T, Ohuchi H, Semina EV, Murray JC, Hamada H, Noji S

Author

Elena V. Semina PhD Chief, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Body Patterning
Chick Embryo
Drosophila Proteins
Embryo, Mammalian
Gene Expression Regulation, Developmental
Genes, Homeobox
Hedgehog Proteins
Homeodomain Proteins
Left-Right Determination Factors
Mice
Models, Genetic
Nuclear Proteins
Paired Box Transcription Factors
Protein Biosynthesis
Proteins
Signal Transduction
Trans-Activators
Transcription Factors
Transforming Growth Factor beta