Nitric oxide and low-density lipoprotein oxidation. Free Radic Res 1998 Jun;28(6):593-600
Date
09/15/1998Pubmed ID
9736311DOI
10.3109/10715769809065815Scopus ID
2-s2.0-0031712739 (requires institutional sign-in at Scopus site) 27 CitationsAbstract
Nitric oxide can have both pro-oxidant and antioxidant effects on low-density lipoprotein. Nitric oxide does not appear to react directly with components of LDL. However, in the presence of oxygen (through NO2 and N2O3 formation) or superoxide (through peroxynitrite formation) nitric oxide may cause oxidation of the lipid, protein and antioxidant components of LDL. Conversely, nitric oxide is a potent inhibitor of LDL oxidation when initiated by copper ions or by azo-initiators. The possible implications of these observations to vascular pathology are discussed.
Author List
Hogg N, Kalyanaraman BAuthors
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinBalaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsCardiovascular Diseases
Humans
Lipoproteins, LDL
Nitrates
Nitric Oxide
Oxidation-Reduction