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Nitric oxide and low-density lipoprotein oxidation. Free Radic Res 1998 Jun;28(6):593-600

Date

09/15/1998

Pubmed ID

9736311

DOI

10.3109/10715769809065815

Scopus ID

2-s2.0-0031712739 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

Nitric oxide can have both pro-oxidant and antioxidant effects on low-density lipoprotein. Nitric oxide does not appear to react directly with components of LDL. However, in the presence of oxygen (through NO2 and N2O3 formation) or superoxide (through peroxynitrite formation) nitric oxide may cause oxidation of the lipid, protein and antioxidant components of LDL. Conversely, nitric oxide is a potent inhibitor of LDL oxidation when initiated by copper ions or by azo-initiators. The possible implications of these observations to vascular pathology are discussed.

Author List

Hogg N, Kalyanaraman B

Authors

Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of Wisconsin
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cardiovascular Diseases
Humans
Lipoproteins, LDL
Nitrates
Nitric Oxide
Oxidation-Reduction