Evaluation of Expression of STAT Genes in Immune-Mediated Polyneuropathies. J Mol Neurosci 2020 Jun;70(6):945-952
Date
02/10/2020Pubmed ID
32036580DOI
10.1007/s12031-020-01494-yScopus ID
2-s2.0-85079213543 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Immune-mediated polyneuropathies are acquired conditions that can be categorized to acute and chronic forms based on the disease course. Although the basic mechanism of these conditions has not been clarified yet, genes that regulate immune responses are putative contributors in their development. In the current study, we assessed expression of signal transducer and activator of transcription (STAT)1-3 and STAT5a genes in peripheral blood of 51 patients and 40 healthy subjects. Expression of STAT1 was higher in female patients compared with female controls (Posterior Beta = 3.622, P = 0.044). The gender*group interaction was significant for this gene which indicates different direction of association in males and females. Expressions of other STAT genes were not different between cases and controls. The diagnostic power of STAT1 in female subjects was estimated to be 0.72 with sensitivity of 68.75% and specificity of 84.62%. There was no significant correlation either between expression of different STAT genes or between their expression and age of study participants. The current study potentiates STAT1 as a putative factor in the pathophysiology of acquired immune-mediated polyneuropathies in females and suggests conduction of further functional studies to elaborate the molecular mechanism of this contribution.
Author List
Ali ZPM, Taheri M, Sangsefidi S, Arsang-Jang S, Mazdeh M, Zamani A, Ghafouri-Fard S, Eftekharian MMAuthor
Shahram Arsang-Jang Postdoctoral Fellow in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultFemale
Humans
Male
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
STAT Transcription Factors
