Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. Sci Adv 2019 Jul;5(7):eaaw5296
Date
07/10/2019Pubmed ID
31281895Pubmed Central ID
PMC6611690DOI
10.1126/sciadv.aaw5296Scopus ID
2-s2.0-85068588571 (requires institutional sign-in at Scopus site) 120 CitationsAbstract
Studies of the peripheral nervous system rely on controlled manipulation of neuronal function with pharmacologic and/or optogenetic techniques. Traditional hardware for these purposes can cause notable damage to fragile nerve tissues, create irritation at the biotic/abiotic interface, and alter the natural behaviors of animals. Here, we present a wireless, battery-free device that integrates a microscale inorganic light-emitting diode and an ultralow-power microfluidic system with an electrochemical pumping mechanism in a soft platform that can be mounted onto target peripheral nerves for programmed delivery of light and/or pharmacological agents in freely moving animals. Biocompliant designs lead to minimal effects on overall nerve health and function, even with chronic use in vivo. The small size and light weight construction allow for deployment as fully implantable devices in mice. These features create opportunities for studies of the peripheral nervous system outside of the scope of those possible with existing technologies.
Author List
Zhang Y, Mickle AD, Gutruf P, McIlvried LA, Guo H, Wu Y, Golden JP, Xue Y, Grajales-Reyes JG, Wang X, Krishnan S, Xie Y, Peng D, Su CJ, Zhang F, Reeder JT, Vogt SK, Huang Y, Rogers JA, Gereau RW 4thAuthor
Aaron David Mickle PhD Associate Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain
Humans
Mice
Neurotransmitter Agents
Optogenetics
Peripheral Nerves
Prostheses and Implants
Wireless Technology
