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Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Lett 2011 Nov 09;11(11):4932-8

Date

10/05/2011

Pubmed ID

21967244

Pubmed Central ID

PMC3212653

DOI

10.1021/nl2028766

Abstract

The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.

Author List

Patra CR, Kim JH, Pramanik K, d'Uscio LV, Patra S, Pal K, Ramchandran R, Strano MS, Mukhopadhyay D

Author

Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cells, Cultured
Endothelial Cells
Humans
Inorganic Chemicals
Nanoparticles
Neovascularization, Physiologic
Reactive Oxygen Species
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d