Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Lett 2011 Nov 09;11(11):4932-8
Date
10/05/2011Pubmed ID
21967244Pubmed Central ID
PMC3212653DOI
10.1021/nl2028766Scopus ID
2-s2.0-80755142772 (requires institutional sign-in at Scopus site) 80 CitationsAbstract
The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.
Author List
Patra CR, Kim JH, Pramanik K, d'Uscio LV, Patra S, Pal K, Ramchandran R, Strano MS, Mukhopadhyay DAuthor
Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Cells, CulturedEndothelial Cells
Humans
Inorganic Chemicals
Nanoparticles
Neovascularization, Physiologic
Reactive Oxygen Species