Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Lett 2011 Nov 09;11(11):4932-8

Date

10/05/2011

Pubmed ID

21967244

Pubmed Central ID

PMC3212653

DOI

10.1021/nl2028766

Scopus ID

2-s2.0-80755142772 (requires institutional sign-in at Scopus site)   80 Citations

Abstract

The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.

Author List

Patra CR, Kim JH, Pramanik K, d'Uscio LV, Patra S, Pal K, Ramchandran R, Strano MS, Mukhopadhyay D

Author

Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cells, Cultured
Endothelial Cells
Humans
Inorganic Chemicals
Nanoparticles
Neovascularization, Physiologic
Reactive Oxygen Species