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Nitric oxide and lipid peroxidation. Biochim Biophys Acta 1999 May 05;1411(2-3):378-84

Date

05/13/1999

Pubmed ID

10320670

DOI

10.1016/s0005-2728(99)00027-4

Scopus ID

2-s2.0-0032899132 (requires institutional sign-in at Scopus site)   327 Citations

Abstract

Nitric oxide can both promote and inhibit lipid peroxidation. By itself, nitric oxide acts as a potent inhibitor of the lipid peroxidation chain reaction by scavenging propagatory lipid peroxyl radicals. In addition, nitric oxide can also inhibit many potential initiators of lipid peroxidation, such as peroxidase enzymes. However, in the presence of superoxide, nitric oxide forms peroxynitrite, a powerful oxidant capable of initiating lipid peroxidation and oxidizing lipid soluble antioxidants. The role of nitric oxide in vascular pathology is discussed.

Author List

Hogg N, Kalyanaraman B

Authors

Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of Wisconsin
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arteriosclerosis
Free Radical Scavengers
Humans
Lipid Peroxidation
Nitric Oxide
Peroxides