Effect of neonatal hypoxia on the development of hepatic lipase in the rat. Am J Physiol Regul Integr Comp Physiol 2000 Oct;279(4):R1341-7
Date
09/27/2000Pubmed ID
11004003DOI
10.1152/ajpregu.2000.279.4.R1341Scopus ID
2-s2.0-0033680684 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Increases in plasma lipids occur during hypoxia in suckling but not in weaned rats and may result from altered hepatic enzyme activity. We exposed rats to 7 days of hypoxia from birth to 7 days of age (suckling) or from 28 to 35 days of age (weaned at day 21). Hypoxia led to an increase in hepatic lipid content in the suckling rat only. Hepatic lipase was decreased to approximately 45% of control in 7-day-old rats exposed to hypoxia but not in hypoxic 35-day-old rats. Hypoxic suckling rats also had a 50% reduction in lactate dehydrogenase activity, whereas transaminase activity and CYP1A and CYP3A protein content were not different between hypoxic and normoxic groups. Additional rats were studied 7 and 14 days after recovery from hypoxic exposure from birth to 7 days of age; hepatic lipase activity had recovered to 85% by 7 days and to 100% by 14 days in the rats previously exposed to hypoxia. Administration of dexamethasone to neonatal rats to simulate the hyperglucocorticoid state found in hypoxic 7-day-old rats led to a moderate decrease ( approximately 75% of control) in hepatic lipases. Developmentally, in the normoxic state, hepatic lipases increased rapidly after birth and reached levels more than twofold that of the newborn by 7 days of age. Hypoxia delays the maturation of hepatic lipases. We suggest that the decrease in hepatic lipase activity contributes to hyperlipemia in the hypoxic newborn rats.
Author List
Lee PC, Jelinek B, Struve M, Bruder ED, Raff HAuthor
Hershel Raff PhD Professor in the Academic Affairs department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingAlanine Transaminase
Animals
Animals, Newborn
Aryl Hydrocarbon Hydroxylases
Aspartate Aminotransferases
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Dexamethasone
Female
Hypoxia
L-Lactate Dehydrogenase
Lipase
Liver
Male
Oxidoreductases, N-Demethylating
Rats
Rats, Sprague-Dawley
Reference Values
