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Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. Trends Immunol 2005 Nov;26(11):603-7

Date

09/06/2005

Pubmed ID

16140038

DOI

10.1016/j.it.2005.08.012

Scopus ID

2-s2.0-28444484693   20 Citations

Abstract

Animal model and clinical studies indicate that type 1 diabetes (T1D) results from T cell-mediated autoimmune destruction of insulin-producing pancreatic beta-cells. This review discusses the knowledge gained from animal models about the nature of the autoreactive T cells that cause T1D and the possible basis for their development. Based on this information, the possible positive and negative aspects of various antigen-specific and non-specific immunotherapies, which could potentially prevent the onset of T1D in at risk individuals, are discussed.

Author List

Serreze DV, Chen YG

Author

Yi-Guang Chen PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Autoimmunity
Diabetes Mellitus, Type 1
Disease Models, Animal
Humans
Male
Mice
Models, Immunological
T-Lymphocytes