Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. Trends Immunol 2005 Nov;26(11):603-7
Date
09/06/2005Pubmed ID
16140038DOI
10.1016/j.it.2005.08.012Scopus ID
2-s2.0-28444484693 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Animal model and clinical studies indicate that type 1 diabetes (T1D) results from T cell-mediated autoimmune destruction of insulin-producing pancreatic beta-cells. This review discusses the knowledge gained from animal models about the nature of the autoreactive T cells that cause T1D and the possible basis for their development. Based on this information, the possible positive and negative aspects of various antigen-specific and non-specific immunotherapies, which could potentially prevent the onset of T1D in at risk individuals, are discussed.
Author List
Serreze DV, Chen YGAuthor
Yi-Guang Chen PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAutoimmunity
Diabetes Mellitus, Type 1
Disease Models, Animal
Humans
Male
Mice
Models, Immunological
T-Lymphocytes