Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis. Trans Am Clin Climatol Assoc 2010;121:206-20
Date
08/11/2010Pubmed ID
20697562Pubmed Central ID
PMC2917163Scopus ID
2-s2.0-78650419300 (requires institutional sign-in at Scopus site) 146 CitationsAbstract
CD36 is a multifunctional membrane receptor present on mononuclear phagocytes, platelets, and other cells that serves as a scavenger receptor for oxidized phospholipids, apoptotic cells and certain microbial pathogens. On macrophages, CD36 interaction with oxidized LDL (oxLDL) triggers a signaling response that is pro-inflammatory and pro-atherogenic. The signaling pathway involves activation of src-family kinases, MAP kinases, and Vav family guanine nucleotide exchange factors and results in ligand internalization, foam cell formation and inhibition of migration. On platelets, CD36 interaction with oxLDL and cell-derived microparticles transduces intracellular signals that render them more reactive to low concentrations of classical agonists. In vitro studies and in vivo experiments in CD36 null mice have revealed an important mechanistic role for CD36 in atherosclerosis and thrombosis. Identification of the precise CD36 signaling pathways in specific cells elicited in response to specific ligands may yield novel targets for drug development in athero-thrombotic disorders.
Author List
Silverstein RL, Li W, Park YM, Rahaman SOAuthor
Roy L. Silverstein MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAtherosclerosis
Blood Platelets
CD36 Antigens
Cell-Derived Microparticles
Cytoskeleton
Foam Cells
Hemostasis
Humans
In Vitro Techniques
Lipoproteins, LDL
Macrophages
Mice
Mice, Knockout
Models, Biological
Plaque, Atherosclerotic
Signal Transduction
Thrombosis
