Faculty Collaboration Database

Impaired long-term potentiation in obese zucker rats: possible involvement of presynaptic mechanism. Neuroscience 2003;120(2):535-9

Date

08/02/2003

Pubmed ID

12890522

DOI

10.1016/s0306-4522(03)00297-5

Scopus ID

2-s2.0-0141923480 (requires institutional sign-in at Scopus site)   70 Citations

Abstract

Electrophysiological investigation of basal synaptic transmission and synaptic plasticity in the CA1 region of the hippocampus was carried out in anesthetized obese Zucker rats (OZR). Comparison of the input/output curves of basal field excitatory postsynaptic potential indicates that these are similar in both the OZR and its lean counterpart suggesting that basal synaptic transmission is intact in the OZR. However, high frequency stimulation evokes long-term potentiation (LTP) in the lean rat but not in the OZR. Since post-tetanic potentiation and paired pulse facilitation, forms of short-term potentiation of presynaptic origin, are also severely impaired in the OZR, the results imply that impairment of CA1 hippocampal LTP in these obese rats may be due, in part, to impaired presynaptic function. The results emphasize the potential deleterious effect of obesity on learning and memory functions of the CNS.

Author List

Gerges NZ, Aleisa AM, Alkadhi KA

Author

Nashaat Gerges PhD Chair, Professor in the School of Pharmacy Administration department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Dose-Response Relationship, Radiation
Electric Stimulation
Electrophysiology
Excitatory Postsynaptic Potentials
Long-Term Potentiation
Male
Obesity
Rats
Rats, Zucker
Synaptic Transmission
Thinness
Time Factors