Faculty Collaboration Database

The transfusion effect is influenced by the nature of MHC antigen presentation. Curr Surg 1990;47(5):321-6

Date

09/01/1990

Pubmed ID

2257746

Scopus ID

2-s2.0-0025487316 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

We designed a study to determine whether the mode of presentation of major histocompatibility antigens is important for the ability of donor-specific blood transfusions to prolong organ allograft survival. Donor BN rat whole blood, isolated RBC, RBC ghosts, RBC membrane fragments, or whole blood lysates were administered to Lewis rat recipients 7 days before heterotopic allotransplantation of BN hearts. Only allogeneic whole blood or RBC significantly prolonged cardiac allograft survival in this histoincompatible donor-recipient pair. Whole blood lysates or RBC ghosts and membrane fragments transfused pretransplant did not prolong cardiac allograft survival when compared with syngeneic, transfused control rats. These results suggest that the immunosuppressive effects of donor-specific pretransplant blood transfusion may depend on a three-dimensional spatial relation between cells bearing donor major histocompatibility antigens and recipient responder cells responsible for the transfusion effect.

Author List

Grindel SI, Wiederkehr JC, Pollak R

Author

Steven I. Grindel MD Professor in the Orthopaedic Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood Transfusion
Erythrocyte Transfusion
Erythrocytes
Graft Survival
Histocompatibility Antigens Class I
Male
Rats
Rats, Inbred BN
Rats, Inbred Lew
Transplantation, Homologous