Faculty Collaboration Database

Microsatellite instability in sporadic human breast cancers. Int J Cancer 1996 Nov 15;68(4):447-51

Date

11/15/1996

Pubmed ID

8945614

DOI

10.1002/(SICI)1097-0215(19961115)68:4<447::AID-IJC8>3.0.CO;2-0

Scopus ID

2-s2.0-0029658742 (requires institutional sign-in at Scopus site)   54 Citations

Abstract

Human breast-cancer specimens from 100 patients were analyzed for microsatellite instability (referred to as replication error; RER) at 12 genomic loci on 7 chromosomes, and results were correlated with clinicopathologic characteristics. In 42 of 100 breast-cancer patients, we investigated whether RER was associated with the amplification of oncogenes and/or suppression of tumor-suppressor genes. Of the 100 patients, 8 (8%) were RER-positive at one or more chromosomal loci. The majority of RER-positive patients had early-stage disease with ER-positive tumors, suggesting that RER occurs early in breast tumorigenesis. However, no significant correlation was observed between RER and oncogenes or tumor-suppressor genes. Thus, the mechanism of RER in sporadic human breast cancer may be independent of the multi-step carcinogenesis caused by the alterations of oncogenes and tumor-suppressor genes.

Author List

Toyama T, Iwase H, Yamashita H, Iwata H, Yamashita T, Ito K, Hara Y, Suchi M, Kato T, Nakamura T, Kobayashi S

Author

Mariko Suchi MD, PhD Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Breast Neoplasms
DNA Repair
Female
Genes, Tumor Suppressor
Humans
Microsatellite Repeats
Middle Aged
Oncogenes