Effects of hippocampal injections of a novel ligand selective for the alpha 5 beta 2 gamma 2 subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning. Neurobiol Learn Mem 2002 Jul;78(1):1-10
Date
06/20/2002Pubmed ID
12071663DOI
10.1006/nlme.2001.4050Scopus ID
2-s2.0-0036292157 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
Benzodiazepine pharmacology has led to greater insight into the neural mechanisms underlying learning and anxiety. The synthesis of new compounds capable of modulating responses produced by these receptors has been made possible by the development of an isoform model of the GABA(A)/benzodiazepine receptor complex. In the current experiment, rats were pretreated with several concentrations of the novel ligand RY024 (an alpha 5 beta 2 gamma 2 -selective benzodiazepine receptor inverse agonist) in the hippocampus and were trained in a Pavlovian fear conditioning paradigm. RY024 independently produced fear-related behavior prior to training and, at the highest concentration, decreased the strength of conditioning observed 24 h after training. These data provide further evidence for the involvement of hippocampal GABA(A)/benzodiazepine receptors in learning and anxiety.
Author List
Bailey DJ, Tetzlaff JE, Cook JM, He X, Helmstetter FJAuthors
Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - MilwaukeeJulie Tetzlaff PhD Associate Dean, Associate Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBenzodiazepines
Conditioning, Classical
GABA Agonists
Hippocampus
Injections
Ligands
Male
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, GABA-A
Time Factors
gamma-Aminobutyric Acid
