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The spin trap, alpha-phenyl N-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein. FEBS Lett 1991 Mar 11;280(1):17-20

Date

03/11/1991

Pubmed ID

1849092

DOI

10.1016/0014-5793(91)80194-8

Scopus ID

2-s2.0-0026071271 (requires institutional sign-in at Scopus site)   44 Citations

Abstract

The lipophilic spin trap, N-tert-butylnitrone (PBN) inhibits the formation of the oxidatively-modified low density lipoprotein (LDL) by endothelial cells and by cupric ions. The LDL incubated in the presence of PBN with cells or cupric ions was less readily degraded by macrophages than the LDL incubated in the absence of PBN. A lipid-derived radical formed during oxidation of LDL was detected by spin trapping with PBN. It is likely that PBN inhibits the oxidative and biological modification of LDL by scavenging the LDL-lipid-derived radical.

Author List

Kalyanaraman B, Joseph J, Parthasarathy S

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Copper
Cyclic N-Oxides
Electron Spin Resonance Spectroscopy
Endothelium, Vascular
Female
Free Radicals
Humans
Hydrolysis
Lipid Peroxidation
Lipoproteins, LDL
Macrophages
Mice
Mice, Inbred Strains
Nitrogen Oxides
Rabbits
Spin Labels