The spin trap, alpha-phenyl N-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein. FEBS Lett 1991 Mar 11;280(1):17-20
Date
03/11/1991Pubmed ID
1849092DOI
10.1016/0014-5793(91)80194-8Scopus ID
2-s2.0-0026071271 (requires institutional sign-in at Scopus site) 44 CitationsAbstract
The lipophilic spin trap, N-tert-butylnitrone (PBN) inhibits the formation of the oxidatively-modified low density lipoprotein (LDL) by endothelial cells and by cupric ions. The LDL incubated in the presence of PBN with cells or cupric ions was less readily degraded by macrophages than the LDL incubated in the absence of PBN. A lipid-derived radical formed during oxidation of LDL was detected by spin trapping with PBN. It is likely that PBN inhibits the oxidative and biological modification of LDL by scavenging the LDL-lipid-derived radical.
Author List
Kalyanaraman B, Joseph J, Parthasarathy SAuthor
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCopper
Cyclic N-Oxides
Electron Spin Resonance Spectroscopy
Endothelium, Vascular
Female
Free Radicals
Humans
Hydrolysis
Lipid Peroxidation
Lipoproteins, LDL
Macrophages
Mice
Mice, Inbred Strains
Nitrogen Oxides
Rabbits
Spin Labels