Copper ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide. Biochim Biophys Acta 1990 Nov 14;1096(1):81-3
Date
11/14/1990Pubmed ID
2176549DOI
10.1016/0925-4439(90)90015-hScopus ID
2-s2.0-0026097884 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
The dihydroxy etoposide, a metabolite of the clinically active anticancer drug, VP-16, induced extensive DNA damage in the presence of copper ions. While superoxide dismutase was without any effect on the DNA damage, catalase and inhibitors of free hydroxyl radicals inhibited the DNA degradation, indicating that hydroxyl radicals were responsible for this drug-Cu-dependent DNA damage.
Author List
Sinha BK, Antholine WM, Kalyanaraman B, Eliot HMAuthor
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCatalase
Copper
DNA Damage
Etoposide
Free Radicals
Hydrolysis
Hydroxides
Hydroxyl Radical
Superoxide Dismutase