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Copper ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide. Biochim Biophys Acta 1990 Nov 14;1096(1):81-3

Date

11/14/1990

Pubmed ID

2176549

DOI

10.1016/0925-4439(90)90015-h

Scopus ID

2-s2.0-0026097884 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

The dihydroxy etoposide, a metabolite of the clinically active anticancer drug, VP-16, induced extensive DNA damage in the presence of copper ions. While superoxide dismutase was without any effect on the DNA damage, catalase and inhibitors of free hydroxyl radicals inhibited the DNA degradation, indicating that hydroxyl radicals were responsible for this drug-Cu-dependent DNA damage.

Author List

Sinha BK, Antholine WM, Kalyanaraman B, Eliot HM

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Catalase
Copper
DNA Damage
Etoposide
Free Radicals
Hydrolysis
Hydroxides
Hydroxyl Radical
Superoxide Dismutase