Using zebrafish to study the complex genetics of glaucoma. Comp Biochem Physiol C Toxicol Pharmacol 2004 Jul;138(3):343-50
Date
11/10/2004Pubmed ID
15533792DOI
10.1016/j.cca.2004.03.003Scopus ID
2-s2.0-7944231499 (requires institutional sign-in at Scopus site) 53 CitationsAbstract
The overall goal of this review is to highlight the power of zebrafish as a model system for studying complex diseases which involve multiple genetic loci. We are interested in identifying and characterizing genes implicated in the blinding condition of glaucoma. Glaucoma is a complex disease that often involves multiple genetic loci. Most disease causing and modifying genes for glaucoma remain unidentified. However, several genes that regulate various aspects of ocular development have been shown to associate with glaucoma. With zebrafish, forward and reverse genetic approaches can be combined in order to identify critical genetic interactions required for normal and pathological events in the development and maintenance of the eye.
Author List
McMahon C, Semina EV, Link BAAuthors
Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinElena V. Semina PhD Chief, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsFish Diseases
Glaucoma
Homeodomain Proteins
Humans
LIM-Homeodomain Proteins
Transcription Factors
Zebrafish