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Genetic analysis of prostatic atypical adenomatous hyperplasia (adenosis). Am J Pathol 1999 Sep;155(3):967-71

Date

09/17/1999

Pubmed ID

10487854

Pubmed Central ID

PMC1866890

DOI

10.1016/S0002-9440(10)65196-6

Scopus ID

2-s2.0-0032887984 (requires institutional sign-in at Scopus site)   38 Citations

Abstract

Atypical adenomatous hyperplasia (AAH) of the prostate, a small glandular proliferation, is a putative precursor lesion to prostate cancer, in particular to the subset of well-differentiated carcinomas that arise in the transition zone, the same region where AAH lesions most often occur. Several morphological characteristics of AAH suggest a relationship to cancer; however, no definitive evidence has been reported. In this study, we analyzed DNA from 25 microdissected AAH lesions for allelic imbalance as compared to matched normal DNA, using one marker each from chromosome arms 1q, 6q, 7q, 10q, 13q, 16q, 17p, 17q, and 18q, and 19 markers from chromosome 8p. We observed 12% allelic imbalance, with loss only within chromosome 8p11-12. These results suggest that genetic alterations in transition zone AAH lesions may be infrequent. This genotypic profile of AAH will allow for comparisons with well-differentiated carcinomas in the transition zone of the prostate.

Author List

Doll JA, Zhu X, Furman J, Kaleem Z, Torres C, Humphrey PA, Donis-Keller H

Author

Jennifer A. Doll PhD Assistant Professor in the Biomedical Sciences department at University of Wisconsin - Milwaukee




MESH terms used to index this publication - Major topics in bold

Alleles
Chromosomes, Human
Humans
Loss of Heterozygosity
Male
Microsatellite Repeats
Precancerous Conditions
Prostatic Hyperplasia
Prostatic Neoplasms