Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

The Y's that bind: negative regulators of Src family kinase activity in platelets. J Thromb Haemost 2009 Jul;7 Suppl 1(0 1):195-9

Date

07/28/2009

Pubmed ID

19630799

Pubmed Central ID

PMC4423597

DOI

10.1111/j.1538-7836.2009.03369.x

Scopus ID

2-s2.0-67849133372 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

Members of the Src family of protein tyrosine kinases play important roles in platelet adhesion, activation, and aggregation. The purpose of this review is to summarize current knowledge regarding how Src family kinase activity is regulated in general, to describe what is known about mechanisms underlying SFK activation in platelets, and to discuss platelet proteins that contribute to SFK inactivation, particularly those that use phosphotyrosine-containing sequences to recruit phosphatases and kinases to sites of SFK activity.

Author List

Newman DK

Authors

Debra K. Newman PhD Investigator in the Blood Research Institute department at BloodCenter of Wisconsin
Debra K. Newman PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Blood Platelets
Humans
Phosphotyrosine
src-Family Kinases