The Y's that bind: negative regulators of Src family kinase activity in platelets. J Thromb Haemost 2009 Jul;7 Suppl 1(0 1):195-9
Date
07/28/2009Pubmed ID
19630799Pubmed Central ID
PMC4423597DOI
10.1111/j.1538-7836.2009.03369.xScopus ID
2-s2.0-67849133372 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Members of the Src family of protein tyrosine kinases play important roles in platelet adhesion, activation, and aggregation. The purpose of this review is to summarize current knowledge regarding how Src family kinase activity is regulated in general, to describe what is known about mechanisms underlying SFK activation in platelets, and to discuss platelet proteins that contribute to SFK inactivation, particularly those that use phosphotyrosine-containing sequences to recruit phosphatases and kinases to sites of SFK activity.
Author List
Newman DKAuthors
Debra K. Newman PhD Investigator in the Blood Research Institute department at BloodCenter of WisconsinDebra K. Newman PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Blood PlateletsHumans
Phosphotyrosine
src-Family Kinases