Medical College of Wisconsin
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Debra K. Newman PhD

Debra K. Newman PhD profile photo picture

Investigator

Institution: BloodCenter of Wisconsin
Department: Blood Research Institute

Member of the Cancer Center
Member of the Cardiovascular Center


Research Experience

  • Blood Platelets
  • Phosphotyrosine
  • Platelet Activation
  • Platelet Adhesiveness
  • Platelet Aggregation
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Platelet Membrane Glycoproteins
  • Protein Interaction Domains and Motifs
  • Protein Tyrosine Phosphatases
  • Signal Transduction
  • Publications (82)

  • Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding. (Zwifelhofer NMJ, Bercovitz RS, Cole R, Yan K, Simpson PM, Moroi A, Newman PJ, Niebler RA, Scott JP, Stuth EAD, Woods RK, Benson DW, Newman DK) Thromb Haemost 2020 Jan;120(1):94-106 PMID: 31752040 PMCID: PMC7003188 SCOPUS ID: 2-s2.0-85077799720 11/22/2019       2 Citations
  • Generation of PECAM-1 (CD31) conditional knockout mice. (Zhi H, Kanaji T, Fu G, Newman DK, Newman PJ) Genesis 2020 02;58(2):e23346 PMID: 31729819 PMCID: PMC7021573 SCOPUS ID: 2-s2.0-85075415188 11/16/2019       1 Citation
  • Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation. (Moroi AJ, Zwifelhofer NM, Riese MJ, Newman DK, Newman PJ) Blood Adv 2019 04 09;3(7):1154-1166 PMID: 30967391 PMCID: PMC6457232 SCOPUS ID: 2-s2.0-85068307036 04/11/2019       1 Citation
  • Hemizygosity for the gene encoding glycoprotein Ibβ is not responsible for macrothrombocytopenia and bleeding in patients with 22q11 deletion syndrome. (Zwifelhofer NMJ, Bercovitz RS, Weik LA, Moroi A, LaRose S, Newman PJ, Newman DK) J Thromb Haemost 2019 02;17(2):295-305 PMID: 30549403 PMCID: PMC6410711 SCOPUS ID: 2-s2.0-85060529568 12/15/2018       2 Citations
  • G6b-B: the "Y's" and wherefores. (Newman DK) Blood 2018 09 27;132(13):1359-1360 PMID: 30262581 PMCID: PMC6161768 SCOPUS ID: 2-s2.0-85053899523 09/29/2018       1 Citation
  • Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells. (Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ) J Leukoc Biol 2018 11;104(5):883-893 PMID: 30063264 PMCID: PMC6195461 SCOPUS ID: 2-s2.0-85053248137 08/01/2018       5 Citations
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 07/22/2018    
  • Rotational Thromboelastometry Rapidly Predicts Thrombocytopenia and Hypofibrinogenemia During Neonatal Cardiopulmonary Bypass. (Scott JP, Niebler RA, Stuth EAE, Newman DK, Tweddell JS, Bercovitz RS, Benson DW, Cole R, Simpson PM, Yan K, Woods RK) World J Pediatr Congenit Heart Surg 2018 07;9(4):424-433 PMID: 29945504 SCOPUS ID: 2-s2.0-85055143217 06/28/2018       7 Citations
  • Validation of a definition of excessive postoperative bleeding in infants undergoing cardiac surgery with cardiopulmonary bypass. (Bercovitz RS, Shewmake AC, Newman DK, Niebler RA, Scott JP, Stuth E, Simpson PM, Yan K, Woods RK) J Thorac Cardiovasc Surg 2018 05;155(5):2112-2124.e2 PMID: 29338867 SCOPUS ID: 2-s2.0-85040453070 01/18/2018       8 Citations
  • CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity. (Liao D, Mei H, Hu Y, Newman DK, Newman PJ) Life Sci 2018 Jan 15;193:186-193 PMID: 29122551 PMCID: PMC5754039 SCOPUS ID: 2-s2.0-85033432699 11/11/2017       2 Citations
  • The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function. (Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ) J Biol Chem 2016 Dec 09;291(50):26216-26225 PMID: 27793989 PMCID: PMC5207088 SCOPUS ID: 2-s2.0-85002858868 10/30/2016       14 Citations
  • Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development. (Fu G, Yu M, Chen Y, Zheng Y, Zhu W, Newman DK, Wang D, Wen R) Eur J Immunol 2017 01;47(1):74-83 PMID: 27759161 PMCID: PMC5559087 SCOPUS ID: 2-s2.0-84999652051 10/21/2016       4 Citations
  • A whole blood model of thrombocytopenia that controls platelet count and hematocrit. (Bercovitz RS, Brenner MK, Newman DK) Ann Hematol 2016 Oct;95(11):1887-94 PMID: 27515424 PMCID: PMC6055520 SCOPUS ID: 2-s2.0-84981501486 08/16/2016       3 Citations
  • The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function. (Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ) Sci Signal 2016 Mar 08;9(418):ra27 PMID: 26956486 PMCID: PMC5087802 SCOPUS ID: 2-s2.0-84960380725 03/10/2016       8 Citations
  • Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery. (Brenner MK, Clarke S, Mahnke DK, Simpson P, Bercovitz RS, Tomita-Mitchell A, Mitchell ME, Newman DK) Pediatr Res 2016 Feb;79(2):318-24 PMID: 26492284 PMCID: PMC5114022 SCOPUS ID: 2-s2.0-84982285447 10/23/2015       14 Citations
  • Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. (Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ) PLoS One 2015;10(8):e0135738 PMID: 26291522 PMCID: PMC4546160 SCOPUS ID: 2-s2.0-84942901879 08/21/2015       19 Citations
  • CLEC-2: the inside story. (Newman DK) Blood 2015 Jun 25;125(26):3972-4 PMID: 26113533 PMCID: PMC4481588 SCOPUS ID: 2-s2.0-84933567256 06/27/2015       2 Citations
  • Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo. (Clement M, Fornasa G, Loyau S, Morvan M, Andreata F, Guedj K, Khallou-Laschet J, Larghi P, Le Roux D, Bismuth G, Chiocchia G, Hivroz C, Newman DK, Nicoletti A, Caligiuri G) J Autoimmun 2015 Jan;56:23-33 PMID: 25277651 SCOPUS ID: 2-s2.0-84920288556 10/04/2014       13 Citations
  • B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. (Zheng Y, Wang AW, Yu M, Padmanabhan A, Tourdot BE, Newman DK, White GC, Aster RH, Wen R, Wang D) Blood 2014 Feb 06;123(6):931-4 PMID: 24357731 PMCID: PMC3916881 SCOPUS ID: 2-s2.0-84897574667 12/21/2013       19 Citations
  • PECAM-1 (Newman PJ, Newman DK) Platelets 2013:283-293 SCOPUS ID: 2-s2.0-84882735326 08/27/2013    
  • Signal Transduction During Platelet Plug Formation (Brass LF, Newman DK, Wannermacher K, Zhu L, Stalker TJ) Platelets 2013:367-398 SCOPUS ID: 2-s2.0-84878637476 08/27/2013    
  • Critical role for mouse marginal zone B cells in PF4/heparin antibody production. (Zheng Y, Yu M, Podd A, Yuan L, Newman DK, Wen R, Arepally G, Wang D) Blood 2013 Apr 25;121(17):3484-92 PMID: 23460609 PMCID: PMC3637017 SCOPUS ID: 2-s2.0-84879407772 03/06/2013       28 Citations
  • Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1. (Tourdot BE, Brenner MK, Keough KC, Holyst T, Newman PJ, Newman DK) Biochemistry 2013 Apr 16;52(15):2597-608 PMID: 23418871 PMCID: PMC3666314 SCOPUS ID: 2-s2.0-84876268989 02/20/2013       23 Citations
  • Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. (Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ) Blood 2013 Mar 07;121(10):1858-67 PMID: 23264598 PMCID: PMC3591804 SCOPUS ID: 2-s2.0-84876238476 12/25/2012       62 Citations
  • Platelet signaling. (Stalker TJ, Newman DK, Ma P, Wannemacher KM, Brass LF) Handb Exp Pharmacol 2012(210):59-85 PMID: 22918727 PMCID: PMC4785017 SCOPUS ID: 2-s2.0-84867167320 08/25/2012       71 Citations
  • Cadherin 6 has a functional role in platelet aggregation and thrombus formation. (Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, Newman PJ, Ni H, Kenny D) Arterioscler Thromb Vasc Biol 2012 Jul;32(7):1724-31 PMID: 22539596 PMCID: PMC4155514 SCOPUS ID: 2-s2.0-84865282307 04/28/2012       33 Citations
  • A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. (Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF) Blood 2012 Feb 23;119(8):1935-45 PMID: 22210881 PMCID: PMC3293648 SCOPUS ID: 2-s2.0-84857520121 01/03/2012       38 Citations
  • PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. (Privratsky JR, Tilkens SB, Newman DK, Newman PJ) Life Sci 2012 Jan 30;90(5-6):177-84 PMID: 22119535 PMCID: PMC3264774 SCOPUS ID: 2-s2.0-84856097476 11/29/2011       13 Citations
  • Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. (Privratsky JR, Paddock CM, Florey O, Newman DK, Muller WA, Newman PJ) J Cell Sci 2011 May 01;124(Pt 9):1477-85 PMID: 21486942 PMCID: PMC3078814 SCOPUS ID: 2-s2.0-79955525883 04/14/2011       61 Citations
  • Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. (Paddock C, Lytle BL, Peterson FC, Holyst T, Newman PJ, Volkman BF, Newman DK) Blood 2011 Jun 02;117(22):6012-23 PMID: 21464369 PMCID: PMC3112045 SCOPUS ID: 2-s2.0-79958011812 04/06/2011       27 Citations
  • Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. (Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ) Blood 2011 May 05;117(18):4946-52 PMID: 21368290 PMCID: PMC3100701 SCOPUS ID: 2-s2.0-79955964309 03/04/2011       83 Citations
  • Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. (Ming Z, Hu Y, Xiang J, Polewski P, Newman PJ, Newman DK) Blood 2011 Apr 07;117(14):3903-6 PMID: 21297004 PMCID: PMC3083302 SCOPUS ID: 2-s2.0-79953835599 02/08/2011       35 Citations
  • Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression. (McCormick ME, Goel R, Fulton D, Oess S, Newman D, Tzima E) Arterioscler Thromb Vasc Biol 2011 Mar;31(3):643-9 PMID: 21183735 PMCID: PMC3041848 SCOPUS ID: 2-s2.0-79952188007 12/25/2010       21 Citations
  • Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii. (Keane C, Petersen H, Reynolds K, Newman DK, Cox D, Jenkinson HF, Newman PJ, Kerrigan SW) Arterioscler Thromb Vasc Biol 2010 Dec;30(12):2408-15 PMID: 21071690 PMCID: PMC4098661 SCOPUS ID: 2-s2.0-78650418323 11/13/2010       19 Citations
  • Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. (Moraes LA, Barrett NE, Jones CI, Holbrook LM, Spyridon M, Sage T, Newman DK, Gibbins JM) J Thromb Haemost 2010 Nov;8(11):2530-41 PMID: 20723025 PMCID: PMC3298659 SCOPUS ID: 2-s2.0-78149258905 08/21/2010       31 Citations
  • PECAM-1: conflicts of interest in inflammation. (Privratsky JR, Newman DK, Newman PJ) Life Sci 2010 Jul 17;87(3-4):69-82 PMID: 20541560 PMCID: PMC2917326 SCOPUS ID: 2-s2.0-77954312649 06/15/2010       106 Citations
  • PECAM-1 functions as a negative regulator of laminin-induced platelet activation. (Crockett J, Newman DK, Newman PJ) J Thromb Haemost 2010 Jul;8(7):1584-93 PMID: 20403098 PMCID: PMC2909358 SCOPUS ID: 2-s2.0-77955032687 04/21/2010       12 Citations
  • TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. (Fornasa G, Groyer E, Clement M, Dimitrov J, Compain C, Gaston AT, Varthaman A, Khallou-Laschet J, Newman DK, Graff-Dubois S, Nicoletti A, Caligiuri G) J Immunol 2010 May 15;184(10):5485-92 PMID: 20400708 PMCID: PMC3110943 SCOPUS ID: 2-s2.0-77954732170 04/20/2010       41 Citations
  • Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1. (Bayat B, Werth S, Sachs UJ, Newman DK, Newman PJ, Santoso S) J Immunol 2010 Apr 01;184(7):3889-96 PMID: 20194726 PMCID: PMC4154536 SCOPUS ID: 2-s2.0-77951632493 03/03/2010       46 Citations
  • The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B. (Privratsky JR, Tourdot BE, Newman DK, Newman PJ) J Immunol 2010 Mar 15;184(6):3157-63 PMID: 20173029 PMCID: PMC3628820 SCOPUS ID: 2-s2.0-77951928514 02/23/2010       9 Citations
  • PI3Kbeta goes to the head of its class. (Newman DK) Blood 2009 Sep 03;114(10):2011-2 PMID: 19729533 09/05/2009    
  • The Y's that bind: negative regulators of Src family kinase activity in platelets. (Newman DK) J Thromb Haemost 2009 Jul;7 Suppl 1:195-9 PMID: 19630799 PMCID: PMC4423597 SCOPUS ID: 2-s2.0-67849133372 07/28/2009       18 Citations
  • Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain. (Gao C, Boylan B, Bougie D, Gill JC, Birenbaum J, Newman DK, Aster RH, Newman PJ) J Clin Invest 2009 Mar;119(3):504-11 PMID: 19197137 PMCID: PMC2648674 SCOPUS ID: 2-s2.0-65649101237 02/07/2009       46 Citations
  • Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice. (Goel R, Schrank BR, Arora S, Boylan B, Fleming B, Miura H, Newman PJ, Molthen RC, Newman DK) Arterioscler Thromb Vasc Biol 2008 Nov;28(11):1996-2002 PMID: 18669884 PMCID: PMC3013511 SCOPUS ID: 2-s2.0-55449106035 08/02/2008       75 Citations
  • Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets. (Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ) Blood 2008 Oct 01;112(7):2780-6 PMID: 18641368 PMCID: PMC2556613 SCOPUS ID: 2-s2.0-53449089830 07/22/2008       122 Citations
  • An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling. (Bergom C, Paddock C, Gao C, Holyst T, Newman DK, Newman PJ) J Cell Sci 2008 Apr 15;121(Pt 8):1235-42 PMID: 18388311 PMCID: PMC2567807 SCOPUS ID: 2-s2.0-44449095569 04/05/2008       11 Citations
  • PECAM-1 (Novinska MS, Rathore V, Newman DK, Newman PJ) Platelets 2007:221-230 SCOPUS ID: 2-s2.0-72049117947 12/01/2007    
  • The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis. (Goel R, Boylan B, Gruman L, Newman PJ, North PE, Newman DK) Am J Physiol Gastrointest Liver Physiol 2007 Dec;293(6):G1205-14 PMID: 17932230 SCOPUS ID: 2-s2.0-37149007780 10/13/2007       29 Citations
  • High-throughput phosphotyrosine profiling using SH2 domains. (Machida K, Thompson CM, Dierck K, Jablonowski K, Kärkkäinen S, Liu B, Zhang H, Nash PD, Newman DK, Nollau P, Pawson T, Renkema GH, Saksela K, Schiller MR, Shin DG, Mayer BJ) Mol Cell 2007 Jun 22;26(6):899-915 PMID: 17588523 SCOPUS ID: 2-s2.0-34250641161 06/26/2007       133 Citations
  • Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. (Rathore VB, Okada M, Newman PJ, Newman DK) Biochem J 2007 Apr 15;403(2):275-81 PMID: 17233630 PMCID: PMC1874248 SCOPUS ID: 2-s2.0-34247134920 01/20/2007       23 Citations
  • Functions of platelet-endothelial cell adhesion molecule-1 in the vascular endothelium (Newman PJ, Newman DK) Endothelial Biomedicine 1 January 2007:1037-1048 SCOPUS ID: 2-s2.0-84928865426 01/01/2007    
  • The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy. (Bergom C, Goel R, Paddock C, Gao C, Newman DK, Matsuyama S, Newman PJ) Cancer Biol Ther 2006 Dec;5(12):1699-707 PMID: 17106245 SCOPUS ID: 2-s2.0-33846947172 11/16/2006       24 Citations
  • The alleles of PECAM-1. (Novinska MS, Pietz BC, Ellis TM, Newman DK, Newman PJ) Gene 2006 Jul 05;376(1):95-101 PMID: 16581204 PMCID: PMC2965460 SCOPUS ID: 2-s2.0-33745248698 04/04/2006       26 Citations
  • Platelet PECAM-1 inhibits thrombus formation in vivo. (Falati S, Patil S, Gross PL, Stapleton M, Merrill-Skoloff G, Barrett NE, Pixton KL, Weiler H, Cooley B, Newman DK, Newman PJ, Furie BC, Furie B, Gibbins JM) Blood 2006 Jan 15;107(2):535-41 PMID: 16166583 PMCID: PMC1895610 SCOPUS ID: 2-s2.0-30444452396 09/17/2005       151 Citations
  • Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. (Liu Y, Bubolz AH, Shi Y, Newman PJ, Newman DK, Gutterman DD) Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R57-65 PMID: 16166207 SCOPUS ID: 2-s2.0-33644840773 09/17/2005       33 Citations
  • An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. (Wen R, Chen Y, Schuman J, Fu G, Yang S, Zhang W, Newman DK, Wang D) EMBO J 2004 Oct 13;23(20):4007-17 PMID: 15372077 PMCID: PMC524341 SCOPUS ID: 2-s2.0-8144221736 09/17/2004       29 Citations
  • Phospholipase Cgamma2 contributes to stable thrombus formation on VWF. (Rathore V, Wang D, Newman DK, Newman PJ) FEBS Lett 2004 Aug 27;573(1-3):26-30 PMID: 15327970 SCOPUS ID: 2-s2.0-4344564590 08/26/2004       13 Citations
  • Endothelial cell PECAM-1 confers protection against endotoxic shock. (Maas M, Stapleton M, Bergom C, Mattson DL, Newman DK, Newman PJ) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H159-64 PMID: 15319204 SCOPUS ID: 2-s2.0-11144278572 08/21/2004       82 Citations
  • Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. (Boylan B, Chen H, Rathore V, Paddock C, Salacz M, Friedman KD, Curtis BR, Stapleton M, Newman DK, Kahn ML, Newman PJ) Blood 2004 Sep 01;104(5):1350-5 PMID: 15150079 SCOPUS ID: 2-s2.0-4444244926 05/20/2004       114 Citations
  • Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. (Maas M, Wang R, Paddock C, Kotamraju S, Kalyanaraman B, Newman PJ, Newman DK) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2336-44 PMID: 12893640 SCOPUS ID: 2-s2.0-0344616889 08/02/2003       21 Citations
  • PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets. (Rathore V, Stapleton MA, Hillery CA, Montgomery RR, Nichols TC, Merricks EP, Newman DK, Newman PJ) Blood 2003 Nov 15;102(10):3658-64 PMID: 12893757 SCOPUS ID: 2-s2.0-0242411524 08/02/2003       68 Citations
  • Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology. (Newman PJ, Newman DK) Arterioscler Thromb Vasc Biol 2003 Jun 01;23(6):953-64 PMID: 12689916 SCOPUS ID: 2-s2.0-0038120892 04/12/2003       300 Citations
  • PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis. (Gao C, Sun W, Christofidou-Solomidou M, Sawada M, Newman DK, Bergom C, Albelda SM, Matsuyama S, Newman PJ) Blood 2003 Jul 01;102(1):169-79 PMID: 12649141 SCOPUS ID: 2-s2.0-0038508862 03/22/2003       96 Citations
  • Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. (Newman DK, Hoffman S, Kotamraju S, Zhao T, Wakim B, Kalyanaraman B, Newman PJ) Biochem Biophys Res Commun 2002 Sep 06;296(5):1171-9 PMID: 12207897 SCOPUS ID: 2-s2.0-0036392047 09/05/2002       34 Citations
  • Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck). (Newman DK, Hamilton C, Newman PJ) Blood 2001 Apr 15;97(8):2351-7 PMID: 11290597 SCOPUS ID: 2-s2.0-0035871812 04/06/2001       106 Citations
  • Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen. (Patil S, Newman DK, Newman PJ) Blood 2001 Mar 15;97(6):1727-32 PMID: 11238114 SCOPUS ID: 2-s2.0-0035869434 03/10/2001       133 Citations
  • Inhibition of antigen-receptor signaling by platelet endothelial cell adhesion molecule-1 (cd31) requires apf intact itim, shp-2, and p56lck (Newman DK, Hamilton CA, Armstrong MJ, Newman PJ) Blood 2000;96(11 PART I) SCOPUS ID: 2-s2.0-33748639234 12/01/2000    
  • Invariant chains with the class II binding site replaced by a sequence from influenza virus matrix protein constrain low-affinity sequences to MHC II presentation. (Carstens C, Newman DK, Bohlen H, König A, Koch N) Int Immunol 2000 Nov;12(11):1561-8 PMID: 11058576 SCOPUS ID: 2-s2.0-0033739254 11/04/2000       9 Citations
  • A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction. (Newton-Nash DK, Newman PJ) J Immunol 1999 Jul 15;163(2):682-8 PMID: 10395658 SCOPUS ID: 2-s2.0-0033565294 07/08/1999       136 Citations
  • Interferon-gamma secretion defects in haemophilia A patients receiving highly purified plasma-derived or recombinant factor VIII. (Newton-Nash DK, Tollerud D, Guevarra L, Gill JC) Br J Haematol 1996 Dec;95(3):554-60 PMID: 8943901 12/01/1996       6 Citations
  • T cell recognition of MHC class II-associated peptides is independent of peptide affinity for MHC and sodium dodecyl sulfate stability of the peptide/MHC complex. Effects of conservative amino acid substitutions at anchor position 1 of influenza matrix protein19-31. (Wu S, Gorski J, Eckels DD, Newton-Nash DK) J Immunol 1996 May 15;156(10):3815-20 PMID: 8621918 SCOPUS ID: 2-s2.0-0029963942 05/15/1996       21 Citations
  • Bacterial toxin superantigens stimulate all members of susceptible VB gene families. (Yassai M, Newton-Nash D, Gorski J) Ann N Y Acad Sci 1995 Jul 07;756:110-2 PMID: 7645813 SCOPUS ID: 2-s2.0-0029023991 07/07/1995       3 Citations
  • Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome. (Kojima H, Newton-Nash D, Weiss HJ, Zhao J, Sims PJ, Wiedmer T) J Clin Invest 1994 Dec;94(6):2237-44 PMID: 7989579 PMCID: PMC330050 12/01/1994       54 Citations
  • The molecular basis of allorecognition. Assessment of the involvement of peptide. (Newton-Nash DK) Hum Immunol 1994 Oct;41(2):105-11 PMID: 7860354 10/01/1994       11 Citations
  • Differential effect of polymorphism at HLA-DR1 beta-chain positions 85 and 86 on binding and recognition of DR1-restricted antigenic peptides. (Newton-Nash DK, Eckels DD) J Immunol 1993 Mar 01;150(5):1813-21 PMID: 7679697 03/01/1993       62 Citations
  • Effects of localized HLA class II beta chain polymorphism on binding of antigenic peptide and stimulation of T cells. (Newton-Nash DK, Eckels DD) Hum Immunol 1992 Mar;33(3):213-23 PMID: 1618659 03/01/1992       15 Citations
  • T cell receptor and alloimmune thrombocytopenias: a model for autoimmune diseases? (Yassai M, McFarland JG, Newton-Nash D, Newman PJ, Eckels DD, Gorski J) Ann Med Interne (Paris) 1992;143(6):365-70 PMID: 1295386 SCOPUS ID: 2-s2.0-0026468248 01/01/1992       6 Citations
  • Assessment of chemokinetic behavior of inflammatory lung macrophages in a linear under-agarose assay. (Newton-Nash DK, Tonellato P, Swiersz M, Abramoff P) J Leukoc Biol 1990 Oct;48(4):297-305 PMID: 2394943 10/01/1990       6 Citations
  • Pathogenesis of acute pulmonary inflammation in strain 2 and strain 13 guinea pigs. (Newton-Nash DK, Pontzer CH, Kahn L, Garancis JC, Abramoff P) Reg Immunol 1988 Sep-Oct;1(2):111-8 PMID: 3275213 09/01/1988    
  • Cellular immunoregulation of acute pulmonary inflammation in strain 2 guinea pigs. (Pontzer CH, Newton-Nash DK, Garancis JC, Abramoff P) Reg Immunol 1988 Sep-Oct;1(2):119-27 PMID: 2978946 09/01/1988    
  • Failure of exogenous serotonin to inhibit the release of 3H-serotonin induced by electrical field stimulation in superfused goldfish brain slices. (Figueroa HR, Newton DK, Yurgens PB, Olcese JM, Hall TR) Gen Pharmacol 1982;13(2):157-60 PMID: 7095394 01/01/1982    
  • Monoamine oxidase types A and B in the vertebrate brain. (Hall TR, Yurgens PB, Figueroa HR, Urueña G, Olcese JM, Newton DK, Vorwald SR) Comp Biochem Physiol C Comp Pharmacol 1982;71C(1):107-10 PMID: 6121664 01/01/1982       21 Citations
  • Last update: 10/26/2020
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