Pathogenesis of acute pulmonary inflammation in strain 2 and strain 13 guinea pigs. Reg Immunol 1988;1(2):111-8
Date
09/01/1988Pubmed ID
3275213Scopus ID
2-s2.0-0024074718 (requires institutional sign-in at Scopus site)Abstract
An acute inflammatory response was elicited in the lungs of strain 2 and 13 guinea pigs following immunization and aerosol challenge with ovalbumin. The pulmonary inflammatory response, characterized by hemorrhage and influx of inflammatory cells, progressed from initiation at 12-hours postchallenge through resolution at 96-hours postchallenge. Inflammatory and immunoregulatory cells, recovered by bronchoalveolar lavage, showed quantitative changes in their relative contribution to the bronchoalveolar cell infiltrate over the course of inflammation. Changes in concentrations of macrophages and T cells, in particular, are discussed in terms of their possible contributions to initiation and resolution of acute pulmonary inflammation.
Author List
Newton-Nash DK, Pontzer CH, Kahn L, Garancis JC, Abramoff PAuthor
Debra K. Newman PhD Investigator in the Blood Research Institute department at BloodCenter of WisconsinMESH terms used to index this publication - Major topics in bold
Administration, InhalationAnimals
Blood Cell Count
Bronchoalveolar Lavage Fluid
Disease Models, Animal
Female
Guinea Pigs
Hemorrhage
Immunity, Cellular
Immunization
Major Histocompatibility Complex
Male
Ovalbumin
Permeability
Pneumonia
Pulmonary Alveoli
Serum Albumin
