Genetic determinants of obesity-related lipid traits. J Lipid Res 2004 Apr;45(4):610-5
Date
02/03/2004Pubmed ID
14754912Pubmed Central ID
PMC2771634DOI
10.1194/jlr.M300474-JLR200Scopus ID
2-s2.0-1642506267 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs), which affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linkage method that localized a QTL on chromosome 7q35-q36, which linked to variation in levels of plasma triglyceride [TG, logarithm of odds (LOD) score = 3.7] and was suggestive of linkage to LDL-cholesterol (LDL-C, LOD = 2.2). Covariates of the TG linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index or hip circumference. Plasma HDL-cholesterol (HDL-C) levels were suggestively linked to a second QTL on chromosome 12p12.3 (LOD = 2.6). Five other QTLs with lower LOD scores were identified for plasma levels of LDL-C, HDL-C, and total cholesterol. These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity.
Author List
Sonnenberg GE, Krakower GR, Martin LJ, Olivier M, Kwitek AE, Comuzzie AG, Blangero J, Kissebah AHAuthor
Anne E. Kwitek PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Blood GlucoseBody Weights and Measures
Cholesterol
Chromosome Mapping
Chromosomes, Human, Pair 7
Family Health
Female
Genome, Human
Humans
Insulin
Lipids
Male
Obesity
Quantitative Trait Loci
Triglycerides
