NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning. Learn Mem 2013 May 15;20(6):290-4
Date
05/17/2013Pubmed ID
23676200Pubmed Central ID
PMC3677083DOI
10.1101/lm.030510.113Scopus ID
2-s2.0-84879290942 (requires institutional sign-in at Scopus site) 56 CitationsAbstract
Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association. The NR2B subunit confers unique properties to the NMDAR and may differentially regulate these two fear memories. Here we show that NR2A-containing NMDARs mediate trace, delay, and contextual fear memories, but NR2B-containing NMDARs are required only for trace conditioning, consistent with a role for PL mPFC in working memory.
Author List
Gilmartin MR, Kwapis JL, Helmstetter FJAuthor
Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AnimalsConditioning, Operant
Fear
Male
Memory
Phenols
Piperidines
Prefrontal Cortex
Rats
Rats, Long-Evans
Receptors, N-Methyl-D-Aspartate