Faculty Collaboration Database

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning. Learn Mem 2013 May 15;20(6):290-4

Date

05/17/2013

Pubmed ID

23676200

Pubmed Central ID

PMC3677083

DOI

10.1101/lm.030510.113

Scopus ID

2-s2.0-84879290942 (requires institutional sign-in at Scopus site)   56 Citations

Abstract

Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association. The NR2B subunit confers unique properties to the NMDAR and may differentially regulate these two fear memories. Here we show that NR2A-containing NMDARs mediate trace, delay, and contextual fear memories, but NR2B-containing NMDARs are required only for trace conditioning, consistent with a role for PL mPFC in working memory.

Author List

Gilmartin MR, Kwapis JL, Helmstetter FJ

Author

Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Animals
Conditioning, Operant
Fear
Male
Memory
Phenols
Piperidines
Prefrontal Cortex
Rats
Rats, Long-Evans
Receptors, N-Methyl-D-Aspartate