Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin. Learn Mem 2011 Nov;18(11):728-32
Date
10/27/2011Pubmed ID
22028394Pubmed Central ID
PMC3207254DOI
10.1101/lm.023945.111Scopus ID
2-s2.0-84857081906 (requires institutional sign-in at Scopus site) 57 CitationsAbstract
Memory for delay fear conditioning requires the synthesis of new mRNA and protein in the basolateral amygdala. It is currently unknown whether similar molecular processes in the amygdala are required for the formation of trace fear memory, in which a stimulus-free interval is inserted between the conditional stimulus (CS) and unconditional stimulus (UCS). Here, we show that infusion of the protein synthesis inhibitor anisomycin into the basolateral amygdala disrupts consolidation of both trace and delay fear conditioning. This is the first evidence that protein synthesis in the amygdala is necessary for the formation of both trace and delay fear memory.
Author List
Kwapis JL, Jarome TJ, Schiff JC, Helmstetter FJAuthor
Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
Acoustic StimulationAmygdala
Animals
Anisomycin
Conditioning, Classical
Dose-Response Relationship, Drug
Electroshock
Fear
Male
Memory
Protein Synthesis Inhibitors
Rats
Rats, Long-Evans
Reaction Time
Time Factors
