Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression. Behav Neurosci 2003 Feb;117(1):3-10
Date
03/07/2003Pubmed ID
12619902DOI
10.1037//0735-7044.117.1.3Scopus ID
2-s2.0-0037310406 (requires institutional sign-in at Scopus site) 132 CitationsAbstract
Although laboratory animal studies have shown that the amygdala plays multiple roles in conditional fear, less is known about the human amygdala. Human subjects were trained in a Pavlovian fear conditioning paradigm during functional magnetic resonance imaging (fMRI). Brain activity maps correlated with reference waveforms representing the temporal pattern of visual conditional stimuli (CSs) and subject-derived autonomic responses were compared. Subjects receiving paired CS-shock presentations showed greater amygdala activity than subjects receiving unpaired CS-shock presentations when their brain activity was correlated with a waveform generated from their behavioral responses. Stimulus-based waveforms revealed learning differences in the visual cortex, but not in the amygdala. These data support the view that the amygdala is important for the expression of learned behavioral responses during Pavlovian fear conditioning.
Author List
Cheng DT, Knight DC, Smith CN, Stein EA, Helmstetter FJAuthor
Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AdultAmygdala
Autonomic Nervous System
Conditioning, Classical
Electrophysiology
Fear
Female
Humans
Learning
Magnetic Resonance Imaging
Male
Middle Aged
Visual Cortex
