Hypoalgesia in response to sensitization during acute noise stress. Behav Neurosci 1994 Feb;108(1):177-85
Date
02/01/1994Pubmed ID
8192843DOI
10.1037//0735-7044.108.1.177Scopus ID
2-s2.0-0028351483 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
Three experiments examined the antinociceptive response shown by rats during exposure to loud noise. Noise exposure resulted in a time-dependent elevation of radiant heat tail flick latency that varied as a function of stimulus intensity. Noise stress hypoalgesia in response to a 90-dB stimulus was blocked by pretreatment with the opioid antagonist naltrexone (0.1-7.0 mg/kg). Systemic administration of midazolam (2 mg/kg) prior to exposure to the stressor attenuated the elevation in tail flick latency. Because topographically similar antinociceptive responses may be elicited with a low intensity noise stimulus that has served as a Pavlovian conditional stimulus for shock, the use of this paradigm may permit direct comparisons of associative and nonassociative fear responses using qualitatively similar auditory stimuli.
Author List
Helmstetter FJ, Bellgowan PSAuthor
Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
Acoustic StimulationAnimals
Arousal
Association Learning
Attention
Conditioning, Classical
Fear
Loudness Perception
Male
Midazolam
Naltrexone
Nociceptors
Noise
Pain Threshold
Rats
Reaction Time
Receptors, Opioid
Tail
Thermosensing
