Faculty Collaboration Database

Functional mapping of the rat brain during drinking behavior: a fluorodeoxyglucose study. Physiol Behav 1993 Sep;54(3):605-12

Date

09/01/1993

Pubmed ID

8415957

DOI

10.1016/0031-9384(93)90256-f

Scopus ID

2-s2.0-0027182129 (requires institutional sign-in at Scopus site)   52 Citations

Abstract

Autoradiographic techniques using the radiolabeled glucose analog [14C]2-fluoro-2-deoxy-D-glucose (FDG) were used to map the functional activity in the CNS during drinking behavior. Rats were trained to drink water during a 1-h session each day. Half of the rats were injected with FDG and allowed to drink, while the other half were satiated prior to FDG injection. Uptake of FDG for drinking and control groups of rats was quantified in 60 brain structures from frontal cortex to cervical spinal cord. The largest percent increase in activity (96%) during drinking was in the lateral hypothalamus. Limbic structures with significant metabolic increases included the lateral septum (48%), lateral habenula (44%), and nucleus accumbens (32%). Thalamic nuclei activated included intralaminar (60%), zona incerta (51%), ventroposteromedial (50%), anterior ventral (47%), and dorsal medial (40%). Other structures with increases were the caudal caudate nucleus (53%) and the spinal trigeminal nucleus (45%). The findings were interpreted in light of related metabolic mapping studies of the effects of orofacial stimulation, dehydration, ingestion, arousal, and reward. It was concluded that this FDG study revealed primarily the involvement of structures linked to rewarding and arousal components of motivated drinking behavior, as well as sensorimotor correlates of the orofacial stimulation. The findings provide the first comprehensive functional map of brain systems related to drinking behavior in adult animals.

Author List

Gonzalez-Lima F, Helmstetter FJ, Agudo J

Author

Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Animals
Autoradiography
Blood Glucose
Brain
Brain Mapping
Caudate Nucleus
Deoxyglucose
Drinking Behavior
Fluorodeoxyglucose F18
Hypothalamic Area, Lateral
Limbic System
Male
Rats
Somatosensory Cortex
Thalamic Nuclei
Trigeminal Nucleus, Spinal