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Ethylketocyclazocine and bremazocine analgesia in neonatal rats. Pharmacol Biochem Behav 1988 Aug;30(4):817-21

Date

08/01/1988

Pubmed ID

3067243

DOI

10.1016/0091-3057(88)90105-0

Scopus ID

2-s2.0-0024157702 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

In three experiments we examined the analgesic potency of kappa opioid receptor agonists in 2- and 16-day-old rats. Ethylketocyclazocine (1-50 mg/kg) produced similar dose- and time-dependent increases in the latency to retract a hind paw from a noxious thermal stimulus in rats of both ages. Bremazocine (0.001-10 mg/kg), a kappa agonist with reported antagonist activity at mu receptors, was also effective in producing analgesia in 2-day-old rats. The dose-effect relationship for bremazocine was nonmonotonic. Bremazocine analgesia (0.1 mg/kg) was reversed by both naltrexone and MR2266, a putative kappa opioid antagonist. These results are discussed in terms of the functional integrity of a kappa analgesic system in the developing rat.

Author List

Helmstetter FJ, Calcagnetti DJ, Cramer CP, Fanselow MS

Author

Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - Milwaukee




MESH terms used to index this publication - Major topics in bold

Analgesia
Analgesics
Animals
Animals, Newborn
Benzomorphans
Cyclazocine
Ethylketocyclazocine
Female
Male
Morphinans
Naltrexone
Narcotic Antagonists
Rats