Effect of dietary chronic cadmium exposure on cell-mediated immune response in rhesus monkeys (Macaca mulatta): role of calcium deficiency. Arch Toxicol 1984 Dec;56(2):128-31
Date
12/01/1984Pubmed ID
6532378DOI
10.1007/BF00349085Scopus ID
2-s2.0-0021702447 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
The role of Ca deficiency on the immunomodulatory effects of chronic Cd exposure for a period of 10 weeks in male Rhesus monkeys were assessed by the blastogenic capacity of peripheral blood lymphocytes (PBL) in response to T-cell mitogens, phytohemagglutinin (PHA), and concanavalin A (Con A). Calcium deficiency significantly decreased the blastogenic response to PHA (P less than 0.01) and Con A (P less than 0.05). Although Cd exposure in normal monkeys significantly increased the blastogenic response to Con A (P less than 0.05), Cd exposure in Ca-deficient monkeys produced a further significant decrease in the blastogenic response to Con A (P less than 0.001). Total and ionic Ca were also significantly decreased in plasma of Ca deficient monkeys exposed to Cd. It is possible that these two observations may be related to each other. Thus, it is important to assess the nutritional status of the host while evaluating the immunotoxicological effects of an environmental pollutant.
Author List
Chopra RK, Prasad R, Sharma N, Paliwal VK, Nath RAuthor
Vipin Paliwal PhD Associate Professor in the Physics & Chemistry department at Milwaukee School of EngineeringMESH terms used to index this publication - Major topics in bold
AnimalsCadmium
Calcium
Concanavalin A
Immunity, Cellular
Kidney Cortex
Liver
Lymphocyte Activation
Macaca mulatta
Male
Phytohemagglutinins
Spleen
Tissue Distribution
