Faculty Collaboration Database

Induction of Cd-metallothionein in cadmium exposed monkeys under different nutritional stresses. Toxicol Lett 1984 Jul;22(1):21-6

Date

07/01/1984

Pubmed ID

6431643

DOI

10.1016/0378-4274(84)90040-7

Scopus ID

2-s2.0-0021261301 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

Induction of cadmium metallothionein (MT) in chronic cadmium exposure in Rhesus monkeys undergoing protein calorie malnutrition (PCM) and calcium deficiency has been studied. A positive correlation between cadmium content and levels of MT in kidney, liver, intestine, testis, heart and lung, has been observed. The accumulation of cadmium and synthesis of MT in these tissues was highest in monkeys subjected to cadmium exposure during calcium deficiency. Although more of cadmium is directed towards kidneys of calcium-deficient monkeys the MT-inducing ability of kidney is lower than that of liver. Monkeys on PCM diet also showed enhanced accumulation of cadmium and MT as compared to those on normal diet during cadmium exposure.

Author List

Ravi K, Paliwal VK, Nath R

Author

Vipin Paliwal PhD Associate Professor in the Physics & Chemistry department at Milwaukee School of Engineering

MESH terms used to index this publication - Major topics in bold

Animals
Cadmium Poisoning
Calcium
Diet
Macaca mulatta
Male
Metallothionein
Protein-Energy Malnutrition
Tissue Distribution