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Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs. Radiat Res 2013 Sep;180(3):247-58

Date

08/08/2013

Pubmed ID

23919311

Pubmed Central ID

PMC4042860

DOI

10.1667/RR3292.1

Scopus ID

2-s2.0-84884273934   27 Citations

Abstract

The objective of this study was to determine whether radiation-induced injury to the heart after 10 Gy total body irradiation (TBI) is direct or indirect. Young male WAG/RijCmcr rats received a 10 Gy single dose using TBI, upper hemi-body (UHB) irradiation, lower hemi-body (LHB) irradiation, TBI with the kidneys shielded or LHB irradiation with the intestines shielded. Age-matched, sham-irradiated rats served as controls. The lipid profile, kidney injury, heart and liver morphology and cardiac function were determined up to 120 days after irradiation. LHB, but not UHB irradiation, increased the risk factors for cardiac disease as well as the occurrence of cardiac and kidney injury in a way that was quantitatively and qualitatively similar to that observed after TBI. Shielding of the kidneys prevented the increases in risk factors for cardiac disease. Shielding of the intestines did not prevent the increases in risk factors for cardiac disease. There was no histological evidence of liver injury 120 days after irradiation. Injury to the heart from irradiation appears to be indirect, supporting the notion that injury to abdominal organs, principally the kidneys, is responsible for the increased risk factors for and the occurrence of cardiac disease after TBI and LHB irradiation.

Author List

Lenarczyk M, Lam V, Jensen E, Fish BL, Su J, Koprowski S, Komorowski RA, Harmann L, Migrino RQ, Li XA, Hopewell JW, Moulder JE, Baker JE

Authors

John E. Baker PhD Professor in the Surgery department at Medical College of Wisconsin
Eric S. Jensen DVM Associate Professor in the Research Office department at Medical College of Wisconsin
X Allen Li PhD Professor in the Radiation Oncology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Base Sequence
DNA Primers
Heart
Intestines
Kidney
Male
Radiation Dosage
Radiation Injuries, Experimental
Rats
Risk Factors
Whole-Body Irradiation
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a