The t(14;18) in diffuse large B-cell lymphoma: correlation with germinal center-associated markers and clinical features. Appl Immunohistochem Mol Morphol 2005 Jun;13(2):116-23
Date
05/17/2005Pubmed ID
15894922DOI
10.1097/01.pai.0000129055.93199.2bScopus ID
2-s2.0-19444367343 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
The clinical and biologic relevance of the t(14;18) and features of germinal center (GC) differentiation in diffuse large B-cell lymphoma (DLBCL) remain controversial. The authors examined the association of t(14;18) with GC-associated markers and clinical features in 44 de novo DLBCLs (22 nodal and 22 primary extranodal). CD10, bcl-2, and bcl-6 were expressed in 50%, 62%, and 54% of cases respectively. There were no significant differences in expression of these markers between nodal and extranodal cases. Coexpression of CD10 and bcl-6 was seen in 12 of 41 cases, and was more frequent in nodal than extranodal DLBCL (9 of 21 vs. 3 of 20; P = 0.05). A CD10+/bcl-6+ phenotype was not significantly associated with bcl-2 expression, stage, complete remission rate, or survival. The t(14;18) was found in 7 of 44 (16%) cases (6 nodal, 1 extranodal; P = 0.09). It was associated with a CD10+/bcl-6+ phenotype (5 of 7 vs. 7 of 27; P = 0.015) and a trend toward more frequent bcl-6 expression (6 of 7 vs. 15 of 34; P = 0.09), but no association with bcl-2 expression, CD10, clinical stage, complete remission, or survival. Among nodal or high-stage (III-IV) DLBCL, cases with the t(14;18) showed a trend toward decreased survival (P = 0.12).
Author List
Xu Y, McKenna RW, Doolittle JE, Hladik CL, Kroft SHAuthor
Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
B-Lymphocytes
Child
Child, Preschool
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
DNA-Binding Proteins
Female
Flow Cytometry
Humans
In Situ Hybridization, Fluorescence
Lymphoma, Large B-Cell, Diffuse
Male
Middle Aged
Neprilysin
Proto-Oncogene Proteins c-bcl-6
Translocation, Genetic
